Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the
eukaryotic genome and a focal point for cellular regulation during development …

A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

Regulation of biological processes typically incorporates mechanisms that initiate and
terminate the process and, where understood, these mechanisms often involve feedback …

CCCTC-binding factor (CTCF) is critical to three-dimensional genome organization. Upon
differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We …

Abstract FACT (FAcilitates Chromatin Transcription) has long been considered to be a
transcription elongation factor whose ability to destabilize nucleosomes promotes RNAPII …

During eukaryotic transcription elongation, RNA polymerase II (RNAP2) is regulated by a
chorus of factors. Here, we identified a common binary interaction module consisting of TFIIS …

Eukaryotic transcription is dependent on specific histone modifications. Their recognition by
chromatin readers triggers complex processes relying on the coordinated association of …

Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …

Skeletal muscle gene expression is governed by the myogenic regulatory family (MRF)
which includes MyoD (MYOD1) and myogenin (MYOG). MYOD1 and MYOG are known to …

Recognition of histone-modified nucleosomes by specific reader domains underlies the
regulation of chromatin-associated processes. Whereas structural studies revealed how …