Unraveling the mystery surrounding post-acute sequelae of COVID-19

RK Ramakrishnan, T Kashour, Q Hamid… - Frontiers in …, 2021 - frontiersin.org
More than one year since its emergence, corona virus disease 2019 (COVID-19) is still
looming large with a paucity of treatment options. To add to this burden, a sizeable subset of …

The key role of mitochondrial function in health and disease

I San-Millán - Antioxidants, 2023 - mdpi.com
The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages

EM Schuster, MW Epple, KM Glaser, M Mihlan… - Nature …, 2022 - nature.com
Successful elimination of bacteria in phagocytes occurs in the phago-lysosomal system, but
also depends on mitochondrial pathways. Yet, how these two organelle systems …

Mitochondria shed their outer membrane in response to infection-induced stress

X Li, J Straub, TC Medeiros, C Mehra, F den Brave… - Science, 2022 - science.org
INTRODUCTION Mitochondria are dynamic organelles that coordinate many cellular
functions that are essential for life, including diverse metabolic processes, cell division and …

[HTML][HTML] Plant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infection

S Wang, B He, H Wu, Q Cai, O Ramírez-Sánchez… - Cell Host & Microbe, 2024 - cell.com
Cross-kingdom small RNA trafficking between hosts and microbes modulates gene
expression in the interacting partners during infection. However, whether other RNAs are …

Neutrophil extracellular traps and by-products play a key role in COVID-19: pathogenesis, risk factors, and therapy

AR Thierry, B Roch - Journal of clinical medicine, 2020 - mdpi.com
Understanding of the pathogenesis of the coronavirus disease-2019 (COVID-19) remains
incomplete, particularly in respect to the multi-organ dysfunction it may cause. We were the …

[HTML][HTML] Impact of COVID-19 on mitochondrial-based immunity in aging and age-related diseases

R Ganji, PH Reddy - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) is a deadly pandemic, immune compromised
disease with no cure. The COVID-19 is caused by acute respiratory syndrome corona virus 2 …

Mitochondrial function in development and disease

MP Rossmann, SM Dubois… - Disease models & …, 2021 - journals.biologists.com
Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

[HTML][HTML] SARS-CoV-2 Nsp5 activates NF-κB pathway by upregulating SUMOylation of MAVS

W Li, J Qiao, Q You, S Zong, Q Peng, Y Liu… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 is an infectious disease caused by SARS-CoV-2 infection. A large number of
clinical studies found high-level expression of pro-inflammatory cytokines in patients …

Mitohormesis

YW Cheng, J Liu, T Finkel - Cell Metabolism, 2023 - cell.com
Perturbation of mitochondrial function can trigger a host of cellular responses that seek to
restore cellular metabolism, cytosolic proteostasis, and redox homeostasis. In some cases …