Neuronal signalling is a key element in neuronal communication and is essential for the
proper functioning of the CNS. Astrocytes, the most prominent glia in the brain play a key …

Protein misfolding and accumulation defines a prevailing feature of many
neurodegenerative disorders, finally resulting in the formation of toxic intra-and extracellular …

Cell replacement therapies for Parkinson's disease (PD) based on transplantation of
pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials. Here, we …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that lacks effective
treatment strategies to halt or delay its progression. The homeostasis of Ca2+ ions is crucial …

Brain disorders represent a significant challenge in medical science due to the formidable
blood–brain barrier (BBB), which severely limits the penetration of conventional …

The pathogenesis of Lewy body diseases (LBDs), including Parkinson's disease (PD),
involves α-synuclein (α-Syn) aggregation that originates in peripheral organs and spreads to …

Abstract α-Synuclein (α-Syn) is closely related to the pathogenesis of Parkinson's disease
(PD). Under pathological conditions, the conformation of α-syn changes and different forms …

Parkinson's disease (PD) is characterized by the pathological accumulation of α-synuclein
(α-syn) and loss of dopaminergic neurons in the substantia nigra. Aging is a significant risk …

The ability of oxytocin (OT) to interact with the dopaminergic system through facilitatory D2-
OT receptor (OTR) receptor-receptor interaction in the limbic system is increasingly …

Introduction A key pathological event occurring in Parkinson's disease (PD) is the
transneuronal spreading of alpha-synuclein (α-syn). Other hallmarks of PD include …