This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …

Abstract Purposes of Review Extracellular matrix (ECM) components modulate the
interaction between pancreatic islet cells. During the islet isolation prior to transplantation as …

Scaffolds have been broadly applied within tissue engineering and regenerative medicine to
regenerate, replace, or augment diseased or damaged tissue. For a scaffold to perform …

Objectives: Our study aims at producing acellular extracellular matrix scaffolds from the
human pancreas (hpaECMs) as a first critical step toward the production of a new …

Cell-based therapies for the treatment of diabetes, generally aim to provide long-term
glucose regulated-insulin delivery using insulin producing cells. The delivery platform is …

The extracellular matrix (ECM) is unique to each tissue and capable of guiding cell
differentiation, migration, morphology, and function. The ECM proteome of different …

The combination of patient-specific cells with scaffolds obtained from natural sources may
result in improved regeneration of human tissues. Decellularization of the native tissue is the …

Embryonic and pluripotent stem cells hold great promise in generating β-cells for both
replacing medicine and novel therapeutic discoveries in diabetes mellitus. However, their …

Abstract Background Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic
insulin-producing β cells are specifically destroyed by the immune system. Understanding …

Understanding the organisation and role of the extracellular matrix (ECM) in islets of
Langerhans is critical for maintaining pancreatic β‐cells, and to recognise and revert the …