Alleviating hypoxia to improve cancer immunotherapy
Tumor hypoxia resulting from abnormal and dysfunctional tumor vascular network poses a
substantial obstacle to immunotherapy. In fact, hypoxia creates an immunosuppressive …
substantial obstacle to immunotherapy. In fact, hypoxia creates an immunosuppressive …
[HTML][HTML] Role of interferon-gamma (IFN-γ) and IFN-γ receptor 1/2 (IFNγR1/2) in regulation of immunity, infection, and cancer development: IFN-γ-dependent or …
H Ding, G Wang, Z Yu, H Sun, L Wang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
IFN-γ, a soluble cytokine being produced by T lymphocytes, macrophages, mucosal
epithelial cells, or natural killer cells, is able to bind to the IFN-γ receptor (IFNγR) and in turn …
epithelial cells, or natural killer cells, is able to bind to the IFN-γ receptor (IFNγR) and in turn …
Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies
While regulatory T (Treg) cells are traditionally viewed as professional suppressors of
antigen presenting cells and effector T cells in both autoimmunity and cancer, recent …
antigen presenting cells and effector T cells in both autoimmunity and cancer, recent …
Immunovascular classification of HCC reflects reciprocal interaction between immune and angiogenic tumor microenvironments
Y Kurebayashi, K Matsuda, A Ueno, H Tsujikawa… - Hepatology, 2022 - journals.lww.com
Conclusions HCC can be classified into four distinct immunovascular subtypes (IH/AS,
IM/AM, IL/AG, and IL/AL) that reflect the reciprocal interaction between the antitumor immune …
IM/AM, IL/AG, and IL/AL) that reflect the reciprocal interaction between the antitumor immune …
Quickly evolving near‐infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment
Among modalities of cancer immunotherapy, near‐infrared photoimmunotherapy (NIR‐PIT)
has reached significant preclinical and clinical stages and quickly evolved over the last 5 …
has reached significant preclinical and clinical stages and quickly evolved over the last 5 …
Tumor accomplice: T cell exhaustion induced by chronic inflammation
L Fang, K Liu, C Liu, X Wang, W Ma, W Xu… - Frontiers in …, 2022 - frontiersin.org
The development and response to treatment of tumor are modulated by inflammation, and
chronic inflammation promotes tumor progression and therapy resistance. This article …
chronic inflammation promotes tumor progression and therapy resistance. This article …
Metformin synergizes with PD-1 blockade to promote normalization of tumor vessels via CD8T cells and IFNγ
M Tokumasu, M Nishida, W Zhao, R Chao… - Proceedings of the …, 2024 - pnas.org
Tumor blood vessels are highly leaky in structure and have poor blood perfusion, which
hampers infiltration and function of CD8T cells within tumor. Normalizing tumor vessels is …
hampers infiltration and function of CD8T cells within tumor. Normalizing tumor vessels is …
Simultaneously combined cancer cell-and CTLA4-targeted NIR-PIT causes a synergistic treatment effect in syngeneic mouse models
T Kato, R Okada, A Furusawa, F Inagaki… - Molecular cancer …, 2021 - AACR
Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that utilizes
antibody–IRDye700DX (IR700) conjugates. The clinical use of NIR-PIT has recently been …
antibody–IRDye700DX (IR700) conjugates. The clinical use of NIR-PIT has recently been …
IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3
Y Zhu, L He, Y Zhu, H Yao, J Jiang, H Lu - Molecular Medicine, 2024 - Springer
Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in
preterm infants, characterised by compromised alveolar development and pulmonary …
preterm infants, characterised by compromised alveolar development and pulmonary …
A comprehensive analysis of HAVCR1 as a prognostic and diagnostic marker for pan-cancer
S Liu, W Tang, J Cao, M Shang, H Sun, J Gong… - Frontiers in …, 2022 - frontiersin.org
Hepatitis A virus cellular receptor (HAVCR1) is a type-1 integral membrane glycoprotein that
plays a key role in immunity and renal regeneration and is abnormally expressed in various …
plays a key role in immunity and renal regeneration and is abnormally expressed in various …