An ageing population is a typical feature of many developed countries across the world.
Analyzed from a biomedical and philosophical point of view, this phenomenon is also a …

CD8+ T cell immunological memory of past antigen exposure can confer long-lived
protection against infections or tumors. The fact that CD8+ memory T cells can have features …

The melanoma antigen (MAGE) proteins all contain a MAGE homology domain. MAGE
genes are conserved in all eukaryotes and have expanded from a single gene in lower …

Maternal effect genes (MEGs) encode factors (eg, RNA) that are present in the oocyte and
required for early embryonic development. Hence, while these genes and gene products are …

Throughout our lives, epigenetic processes shape our development and enable us to adapt
to a constantly changing environment. Identifying and understanding environmentally …

Biological sex profoundly conditions organismal development and physiology, imposing
wide-ranging effects on cell signaling, metabolism, and immune response. These effects …

Early patterning of DNA methylation (DNAm) may play an important role in later disease
development. To better understand intergenerational epigenetic inheritance, we …

Simple Summary Glioblastomas, primitive infiltrating brain tumors, are a real public health
problem because of their dismal prognosis. The persistence of aggressive tumor stem cells …

TRIM28 (also known as KAP1 or TIF1β) is the universal co-repressor of the Krüppel-
associated box-containing zinc finger proteins (Krab-ZFPs), the largest family of transcription …

Constitutive heterochromatin at the pericentric regions of chromosomes undergoes dynamic
changes in its epigenetic and spatial organization during spermatogenesis. Accurate control …