Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials. gov and clinicaltrialsregister. eu

RP Garay - Expert opinion on investigational drugs, 2021 - Taylor & Francis
Introduction: Several pharmacological drugs have shown proof of concept for longevity in
animal models. I aimed to identify and review those longevity drug candidates that are …

Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications

B Marchetti, C Giachino, C Tirolo, MF Serapide - Aging Cell, 2022 - Wiley Online Library
Dopamine (DA) signaling via G protein‐coupled receptors is a multifunctional
neurotransmitter and neuroendocrine–immune modulator. The DA nigrostriatal pathway …

Health horizons: Future trends and technologies from the European Medicines Agency's horizon scanning collaborations

V Vignali, PA Hines, AG Cruz, B Ziętek… - Frontiers in medicine, 2022 - frontiersin.org
In medicines development, the progress in science and technology is accelerating.
Awareness of these developments and their associated challenges and opportunities is …

Algorithmic annotation of functional roles for components of 3,044 human molecular pathways

M Sorokin, N Borisov, D Kuzmin, A Gudkov… - Frontiers in …, 2021 - frontiersin.org
Current methods of high-throughput molecular and genomic analyses enabled to
reconstruct thousands of human molecular pathways. Knowledge of molecular pathways …

[HTML][HTML] Plasma acylcarnitine levels increase with healthy aging

ZR Jarrell, MR Smith, X Hu, M Orr, KH Liu… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Acylcarnitines transport fatty acids into mitochondria and are essential for β-oxidation and
energy metabolism. Decreased mitochondrial activity results in increased plasma …

Using proteomic and transcriptomic data to assess activation of intracellular molecular pathways

A Buzdin, V Tkachev, M Zolotovskaia, A Garazha… - Advances in protein …, 2021 - Elsevier
Abstract Analysis of molecular pathway activation is the recent instrument that helps to
quantize activities of various intracellular signaling, structural, DNA synthesis and repair …

山茱萸多糖延缓秀丽隐杆线虫衰老的药效评价及机制研究.

李美霖, 王平, 尹灿, 昝俊峰, 杨可… - Journal of Food …, 2022 - search.ebscohost.com
目的考察山茱萸多糖(Corni Fructus polysaccharides, CFP) 对秀丽隐杆线虫衰老的延缓作用并
探讨其作用机制. 方法以野生型秀丽隐杆线虫(N2 线虫) 作为动物模型, 利用百草枯建立氧化应激 …

[HTML][HTML] An Introductory Guide to Using Bloomington Drosophila Stock Center and FlyBase for Aging Research

X Zheng - Cells, 2024 - mdpi.com
Studies on numerous species have demonstrated strikingly conserved mechanisms that
determine the aging process, from yeasts to worms, flies, zebrafish, mice, and humans. The …

Predicting human chronological age via AI analysis of dorsal hand versus facial images: A study in a cohort of Indian females

A Georgievskaya, T Tlyachev, K Kiselev… - Experimental …, 2024 - Wiley Online Library
Predicting a person's chronological age (CA) from visible skin features using artificial
intelligence (AI) is now commonplace. Often, convolutional neural network (CNN) models …

Potential application of low-intensity pulsed ultrasound in delaying aging for mice

J Chen, W Wang, C Li, Y Xia, H Xu, J Chen, W Chen… - Gerontology, 2022 - karger.com
Introduction: The low-intensity pulsed ultrasound (LIPUS) is one of the popular treatment
modalities allowing to boost the proliferation, differentiation, and migratory activity of cells …