Transforming growth factor-β (TGF-β) is a central player in fibrotic disease. Clinical trials with
global inhibitors of TGF-β have been disappointing, suggesting that a more targeted …

There are many unanswered questions on the relation of intraocular pressure to glaucoma
development and progression. IOP itself cannot be distilled to a single, unifying value …

Unlike common engineering materials, living matter can autonomously respond to
environmental changes. Living structures can grow stronger, weaker, larger, or smaller …

Living systems can grow, develop, adapt, and evolve. These phenomena are non-intuitive to
traditional engineers and often difficult to understand. Yet, classical engineering tools can …

This nontechnical review is focused upon educating the reader on optic nerve head
biomechanics in both aging and disease along two main themes: what is known about how …

Purpose.: We tested the hypothesis that there are age-and race-related differences in
posterior scleral material properties, using eyes from human donors of European (20–90 …

Purpose.: This study investigates the relationship between intraocular pressure (IOP) and
retinal hemodynamics and predicts how arterial blood pressure (BP) and blood flow …

Biomechanics remains an active aspect of glaucoma research, with activity in both basic
science and clinical translation. However, the role of biomechanics in glaucoma remains …

To characterize the material properties of posterior and peripapillary sclera from human
donors, and to investigate the macro-and micro-scale strains as potential control …

Impairments of autoregulation and neurovascular coupling in the optic nerve head play a
critical role in ocular pathologies, especially glaucomatous optic neuropathy. We critically …