The genetic landscape of substance use disorders
Substance use disorders represent a significant public health concern with considerable
socioeconomic implications worldwide. Twin and family-based studies have long …
socioeconomic implications worldwide. Twin and family-based studies have long …
An answered call for aid? Cannabinoid clinical framework for the opioid epidemic
K Hammaker, N Weathington, J Maroon, LW Tang… - Harm Reduction …, 2023 - Springer
Background The opioid crisis continues in full force, as physicians and caregivers are
desperate for resources to help patients with opioid use and chronic pain disorders find …
desperate for resources to help patients with opioid use and chronic pain disorders find …
Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology
Improved understanding of the shared genetic architecture between psychiatric disorders
and brain white matter may provide mechanistic insights for observed phenotypic …
and brain white matter may provide mechanistic insights for observed phenotypic …
Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexus
X Guo, Y Feng, X Ji, N Jia, A Maimaiti, J Lai, Z Wang… - …, 2025 - thelancet.com
Background Increasing evidence suggests a complex interplay between psychiatric
disorders and metabolic dysregulations. However, most research has been limited to …
disorders and metabolic dysregulations. However, most research has been limited to …
A prospective comparison of bipolar i and ii subjects with and without comorbid cannabis use disorders from the COGA dataset
UW Preuss, MN Hesselbrock, VM Hesselbrock - Brain Sciences, 2023 - mdpi.com
Objective: The comorbidity of alcohol and substance use disorders among persons with
bipolar disorder is elevated, as indicated by epidemiological and clinical studies. Following …
bipolar disorder is elevated, as indicated by epidemiological and clinical studies. Following …
The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies
I Austin-Zimmerman, E Spinazzola… - Psychological …, 2024 - cambridge.org
BackgroundThe association between cannabis and psychosis is established, but the role of
underlying genetics is unclear. We used data from the EU-GEI case-control study and UK …
underlying genetics is unclear. We used data from the EU-GEI case-control study and UK …
Enriching ultra-high risk for psychosis cohorts based on accumulated exposure to environmental risk factors for psychotic disorders
B O'Donoghue, D Oliver, H Geros, H Sizer… - Psychological …, 2024 - cambridge.org
Background and hypothesisTransition to psychosis rates within ultra-high risk (UHR)
services have been declining. It may be possible to 'enrich'UHR cohorts based on the …
services have been declining. It may be possible to 'enrich'UHR cohorts based on the …
[HTML][HTML] Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking
EC Johnson, I Austin-Zimmerman, HHA Thorpe… - medRxiv, 2024 - ncbi.nlm.nih.gov
Individuals with schizophrenia frequently experience co-occurring substance use, including
tobacco smoking and heavy cannabis use, and substance use disorders. There is interest in …
tobacco smoking and heavy cannabis use, and substance use disorders. There is interest in …
[HTML][HTML] Immigration status-related exclusive e-cigarette use and cannabis use and their dual use disparities associated with mental health disorder symptoms
Introduction E-cigarette and cannabis use has been linked to various health risks, including
respiratory and cardiovascular conditions. Yet, extant knowledge about the risk factors for …
respiratory and cardiovascular conditions. Yet, extant knowledge about the risk factors for …
The use and potential abuse of psychoactive plants in southern Africa: an overview of evidence and future potential
NZ Nyazema, JT Chanyandura, B Egan - Frontiers in pharmacology, 2024 - frontiersin.org
Background Most Bantu ethnic groups in southern Africa utilize indigenous herbal
medicines, some of which have psychoactive properties. Traditional medical practitioners …
medicines, some of which have psychoactive properties. Traditional medical practitioners …