Substance use disorders represent a significant public health concern with considerable
socioeconomic implications worldwide. Twin and family-based studies have long …

Improved understanding of the shared genetic architecture between psychiatric disorders
and brain white matter may provide mechanistic insights for observed phenotypic …

Background The opioid crisis continues in full force, as physicians and caregivers are
desperate for resources to help patients with opioid use and chronic pain disorders find …

Introduction E-cigarette and cannabis use has been linked to various health risks, including
respiratory and cardiovascular conditions. Yet, extant knowledge about the risk factors for …

Background Most Bantu ethnic groups in southern Africa utilize indigenous herbal
medicines, some of which have psychoactive properties. Traditional medical practitioners …

Objective: The comorbidity of alcohol and substance use disorders among persons with
bipolar disorder is elevated, as indicated by epidemiological and clinical studies. Following …

Individuals with schizophrenia frequently experience co-occurring substance use, including
tobacco smoking and heavy cannabis use, and substance use disorders. There is interest in …

The past two decades have seen the advent and mass application of genome-wide
association studies (GWAS). The observation that complex phenotypes are polygenic has …

Background: Schizophrenia (SCZ) and bipolar disorder (BD) are the result of complex
interactions between genetic vulnerability and environmental factors, including obstetric …

Introduction: The cannabis plant, whose best-known species include sativa, indica, and
rhododendris has been a subject of controversy and debate. It has also been the subject of …