Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Stimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an
endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from …

Neoadjuvant immune checkpoint blockade has shown promising clinical activity. Here, we
characterized early kinetics in tumor-infiltrating and circulating immune cells in oral cancer …

Highlights•Immune fitness in health and disease depends notably on the diversity of cellular
repertoires.•Single-cell sequencing is fostering the understanding of clonal diversity of T-cell …

Simple Summary The TCR is the T cell antigen receptor, and it is responsible of the T cell
activation, through the HLA-antigen complex recognition. Studying the TCR repertoire in …

The T cells are key players of the response to checkpoint blockade immunotherapy (CBI)
and monitoring the strength and specificity of antitumor T-cell reactivity remains a crucial but …

Melanoma is the most aggressive form of skin cancer, representing approximately 4% of all
cutaneous neoplasms it accounts for up to 80% of deaths. Advanced stages of melanoma …

Cutaneous melanoma (CM) is an aggressive form of malignancy with poor prognostic value.
Cuproptosis is a novel type of cell death regulatory mechanism in tumors. However, the role …

Background The combination of platinum-based chemotherapy with immune-checkpoint
inhibitors (ICIs) is a standard of care option in the front-line treatment of advanced non-small …

Definitive management of locoregionally advanced solid tumors presents a major challenge
and often consists of a combination of surgical, radiotherapeutic and systemic therapy …