Background The ability to accurately predict early progression of dengue to severe disease
is crucial for patient triage and clinical management. Previous systematic reviews and meta …

Dengue viruses have spread rapidly within countries and across regions in the past few
decades, resulting in an increased frequency of epidemics and severe dengue disease …

Dengue, caused by four closely related viruses, is a growing global public health concern,
with outbreaks capable of overwhelming health-care systems and disrupting economies …

Dengue virus poses a major threat to global public health: two-thirds of the world's
population is now at risk from infection by this mosquito-borne virus. Dengue virus causes a …

Dengue is widespread throughout the tropics and local spatial variation in dengue virus
transmission is strongly influenced by rainfall, temperature, urbanization and distribution of …

Sequential infection with multiple dengue virus (DENV) serotypes is thought to induce
enduring protection against dengue disease. However, long-term antibody waning has been …

The first approved dengue vaccine has now been licensed in six countries. We propose that
this live attenuated vaccine acts like a silent natural infection in priming or boosting host …

The quest for an effective dengue vaccine has culminated in two approved vaccines and
another that has completed phase 3 clinical trials. However, shortcomings exist in each …

Zika virus (ZIKV) is a mosquito-borne flavivirus responsible for thousands of cases of severe
fetal malformations and neurological disease since its introduction to Brazil in 2013 …

Dengue virus is a mosquito-borne pathogen that causes up to about 100 million cases of
disease each year, placing a major public health, social, and economic burden on …