α1-adrenergic receptors are G-Protein Coupled Receptors that are involved in
neurotransmission and regulate the sympathetic nervous system through binding and …

Lipids represent the most abundant molecular type in the brain with a fat content of
approximately 60% of the dry brain weight in humans. Despite this fact, little attention has …

Norepinephrine (NE) is synthesized in the Locus Coeruleus (LC) of the brainstem, from
where it is released by axonal varicosities throughout the brain via volume transmission. A …

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …

The α1-adrenergic receptors (ARs) are G-protein coupled receptors that bind the
endogenous catecholamines, norepinephrine, and epinephrine. They play a key role in the …

Glutamate is the main excitatory neurotransmitter of the central nervous system (CNS),
released both from neurons and glial cells. Acting via ionotropic (NMDA, AMPA, kainate) …

The medial prefrontal cortex (mPFC) receives dense noradrenergic projections from the
locus coeruleus. Adrenergic innervation of mPFC pyramidal neurons plays an essential role …

Drug-primed reinstatement of cocaine seeking in rats is thought to reflect relapse-like
behavior and is mediated by the integration of signals from mesocorticolimbic dopaminergic …

Stress augments the rewarding memory of cocaine, which plays a critical role in inducing
cocaine craving. However, the neurobiological mechanisms underlying the enhancing effect …

Neuritin is a neurotrophic factor involved in neural development and synaptic plasticity.
However, its role in modulating synaptic transmission remains unclear. Here, we …