B. pseudomallei is the cause of melioidosis, a serious an often fatal disease of humans and
animals. The closely related bacterium B. mallei, which cases glanders, is considered to be …

Circulating full-length osteopontin (FL-OPN) is elevated in plasma from patients with various
infectious diseases, such as adult T-cell leukemia, Mycobacterium tuberculosis (TB) …

Improved diagnostics for acute infections could decrease morbidity and mortality by
increasing early antibiotics for patients with bacterial infections and reducing unnecessary …

Understanding how immune challenges elicit different responses is critical for diagnosing
and deciphering immune regulation. Using a modular strategy to interpret the complex …

Objective: In response to a need for better sepsis diagnostics, several new gene expression
classifiers have been recently published, including the 11-gene “Sepsis MetaScore,” the …

Melioidosis, caused by Burkholderia pseudomallei, is a potentially lethal infection with no
licensed vaccine. There is little understanding of why some exposed individuals have no …

Background The environmental bacterium Burkholderia pseudomallei causes the infectious
disease melioidosis with a high case-fatality rate in tropical and subtropical regions. Direct …

The Gram-negative proteobacteria genus Burkholderia encompasses multiple bacterial
species that are pathogenic to humans and other vertebrates. Two pathogenic species of …

Background: Human visceral leishmaniasis, caused by infection with Leishmania donovani
or L. infantum, is a potentially fatal disease affecting 50,000-90,000 people yearly in 75 …

Burkholderia pseudomallei is the causative agent of melioidosis, which is associated with a
range of clinical manifestations, including sepsis and fatal pneumonia and is endemic in …