Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy

G Sloan, D Selvarajah, S Tesfaye - Nature Reviews Endocrinology, 2021 - nature.com
Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

[HTML][HTML] New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain

EL Feldman, KA Nave, TS Jensen, DLH Bennett - Neuron, 2017 - cell.com
Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic
complications create a substantial burden on both the afflicted patients and society as a …

Diabetic neuropathy: mechanisms, emerging treatments, and subtypes

JW Albers, R Pop-Busui - Current neurology and neuroscience reports, 2014 - Springer
Diabetic neuropathies (DNs) differ in clinical course, distribution, fiber involvement (type and
size), and pathophysiology, the most typical type being a length-dependent distal symmetric …

Diabetic autonomic neuropathy

AI Vinik, RE Maser, BD Mitchell, R Freeman - Diabetes care, 2003 - Am Diabetes Assoc
Diabetic autonomic neuropathy (DAN) is a serious and common complication of diabetes.
Despite its relationship to an increased risk of cardiovascular mortality and its association …

[HTML][HTML] Oxidative stress and nerve damage: role in chemotherapy induced peripheral neuropathy

A Areti, VG Yerra, VGM Naidu, A Kumar - Redox biology, 2014 - Elsevier
Peripheral neuropathy is a severe dose limiting toxicity associated with cancer
chemotherapy. Ever since it was identified, the clear pathological mechanisms underlying …

The role of oxidative stress in the onset and progression of diabetes and its complications: asummary of a Congress Series sponsored byUNESCO‐MCBN, the …

P Rösen, PP Nawroth, G King, W Möller… - Diabetes/metabolism …, 2001 - Wiley Online Library
This review summarises the results and discussions of an UNESCO‐MCBN supported
symposium on oxidative stress and its role in the onset and progression of diabetes. There is …

Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy

NE Cameron, SEM Eaton, MA Cotter, S Tesfaye - Diabetologia, 2001 - Springer
Diabetes mellitus is a major cause of peripheral neuropathy, commonly manifested as distal
symmetrical polyneuropathy. This review examines evidence for the importance of vascular …

Treatment of symptomatic diabetic polyneuropathy with the antioxidant α‐lipoic acid: a meta‐analysis

D Ziegler, H Nowak, P Kempler, P Vargha… - Diabetic …, 2004 - Wiley Online Library
Aims To determine the efficacy and safety of 600 mg of α‐lipoic acid given intravenously
over 3 weeks in diabetic patients with symptomatic polyneuropathy. Methods We searched …

Molecular aspects of lipoic acid in the prevention of diabetes complications

L Packer, K Kraemer, G Rimbach - Nutrition, 2001 - Elsevier
α-Lipoic acid (LA) and its reduced form, dihydrolipoic acid, are powerful antioxidants. LA
scavenges hydroxyl radicals, hypochlorous acid, peroxynitrite, and singlet oxygen …

Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN …

D Ziegler, M Hanefeld, KJ Ruhnau, H Hasche… - Diabetes …, 1999 - Am Diabetes Assoc
OBJECTIVE: To evaluate the efficacy and safety of alpha-lipoic acid given intravenously,
followed by oral treatment in type 2 diabetic patients with symptomatic polyneuropathy …