[HTML][HTML] Molecular targets, therapeutic agents and multitasking nanoparticles to deal with cancer stem cells: A narrative review

A Doustmihan, M Fathi, MA Mazloomi, A Salemi… - Journal of Controlled …, 2023 - Elsevier
There is increasing evidence that malignant tumors are initiated and maintained by a sub-
population of tumor cells that have similar biological properties to normal adult stem cells …

[HTML][HTML] Biological and therapeutic effects of troxerutin: molecular signaling pathways come into view

Z Ahmadi, R Mohammadinejad… - Journal of …, 2021 - ncbi.nlm.nih.gov
Flavonoids consist a wide range of naturally occurring compounds which are exclusively
found in different fruits and vegetables. These medicinal herbs have a number of favourable …

Identification of functional compounds in baru (Dipteryx alata Vog.) nuts: Nutritional value, volatile and phenolic composition, antioxidant activity and antiproliferative …

SC Oliveira-Alves, RS Pereira, AB Pereira… - Food Research …, 2020 - Elsevier
This work aimed to contribute to the nutritional and functional characterization of roasted
baru nuts, a seed widely consumed and produced in Brazil. Baru nut was characterized in …

Curcumin suppresses LGR5 (+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway

X Mao, X Zhang, X Zheng, Y Chen, Z Xuan… - Journal of natural …, 2021 - Springer
Colorectal cancer stem cells (CSCs) have the potential for self-renewal, proliferation, and
differentiation. And LGR5 is a stem cell marker gene of colorectal cancer. Curcumin can …

Dihydroartemisinin inhibits the development of colorectal cancer by GSK-3β/TCF7/MMP9 pathway and synergies with capecitabine

X Dai, W Chen, Y Qiao, X Chen, Y Chen, K Zhang… - Cancer Letters, 2024 - Elsevier
Patients with colorectal cancer (CRC) suffer from poor prognosis and lack effective drugs.
Dihydroartemisinin (DHA) has anti-cancer potential but the mechanism remains unclear. We …

Proanthocyanidins inhibited colorectal cancer stem cell characteristics through Wnt/β‐catenin signaling

Y Chen, Z Yang, X He, W Zhu, Y Wang… - Environmental …, 2023 - Wiley Online Library
Abstract Background Cancer stem cells (CSCs) play a key role in tumor cell growth, drug
resistance, recurrence, and metastasis. Proanthocyanidins (PC) is widely existed in plants …

The relevance of transcription factors in gastric and colorectal cancer stem cells identification and eradication

D Pádua, P Figueira, I Ribeiro, R Almeida… - Frontiers in cell and …, 2020 - frontiersin.org
Gastric and colorectal cancers have a high incidence and mortality worldwide. The presence
of cancer stem cells (CSCs) within the tumor mass has been indicated as the main reason …

Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy

N Taib, M Merhi, V Inchakalody, S Mestiri… - Journal of translational …, 2023 - Springer
Background The mechanism of tumor immune escape and progression in colorectal cancer
(CRC) is widely investigated in-vitro to help understand and identify agents that might play a …

The genetic factors associated with Wnt signaling pathway in colorectal cancer

AS Aghabozorgi, R Ebrahimi, A Bahiraee, SS Tehrani… - Life Sciences, 2020 - Elsevier
Colorectal cancer (CRC) is a common cancer with poor prognosis and high mortality. There
is growing information about the factors involved in the pathogenesis of CRC. However, the …

E2 ubiquitin-conjugating enzymes in cancer: Implications for immunotherapeutic interventions

SM Hosseini, I Okoye, MG Chaleshtari… - Clinica Chimica …, 2019 - Elsevier
Despite the medical advances of the 21st century, the incidence of cancer continues to
increase and the search for a universal cure remains a major health challenge. Our lack of …