Genetic alphabet expansion technology by creating unnatural base pairs
Recent advancements in the creation of artificial extra base pairs (unnatural base pairs,
UBPs) are opening the door to a new research area, xenobiology, and genetic alphabet …
UBPs) are opening the door to a new research area, xenobiology, and genetic alphabet …
Chemical modification of aptamers for increased binding affinity in diagnostic applications: Current status and future prospects
JP Elskens, JM Elskens, A Madder - International journal of molecular …, 2020 - mdpi.com
Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize
analytes with extraordinary target selectivity and affinity. Despite their promising properties …
analytes with extraordinary target selectivity and affinity. Despite their promising properties …
Polymeric vehicles for nucleic acid delivery
AS Piotrowski-Daspit, AC Kauffman… - Advanced drug delivery …, 2020 - Elsevier
Polymeric vehicles are versatile tools for therapeutic gene delivery. Many polymers—when
assembled with nucleic acids into vehicles—can protect the cargo from degradation and …
assembled with nucleic acids into vehicles—can protect the cargo from degradation and …
Recent trends in nucleotide synthesis
B Roy, A Depaix, C Périgaud, S Peyrottes - Chemical Reviews, 2016 - ACS Publications
Focusing on the recent literature (since 2000), this review outlines the main synthetic
approaches for the preparation of 5′-mono-, 5′-di-, and 5′-triphosphorylated …
approaches for the preparation of 5′-mono-, 5′-di-, and 5′-triphosphorylated …
Structural insights into the processing of nucleobase-modified nucleotides by DNA polymerases
A Hottin, A Marx - Accounts of Chemical Research, 2016 - ACS Publications
Conspectus The DNA polymerase-catalyzed incorporation of modified nucleotides is
employed in many biological technologies of prime importance, such as next-generation …
employed in many biological technologies of prime importance, such as next-generation …
DNA catalysis: the chemical repertoire of DNAzymes
M Hollenstein - Molecules, 2015 - mdpi.com
Deoxyribozymes or DNAzymes are single-stranded catalytic DNA molecules that are
obtained by combinatorial in vitro selection methods. Initially conceived to function as gene …
obtained by combinatorial in vitro selection methods. Initially conceived to function as gene …
Enzymatic synthesis of base-functionalized nucleic acids for sensing, cross-linking, and modulation of protein–DNA binding and transcription
M Hocek - Accounts of Chemical Research, 2019 - ACS Publications
Conspectus Protein–DNA interactions are important in replication, transcription, repair, as
well as epigenetic modifications of DNA, which involve methylation and demethylation of …
well as epigenetic modifications of DNA, which involve methylation and demethylation of …
Synthesis of base-modified 2′-deoxyribonucleoside triphosphates and their use in enzymatic synthesis of modified DNA for applications in bioanalysis and chemical …
M Hocek - The Journal of organic chemistry, 2014 - ACS Publications
The synthesis of 2′-deoxyribonucleoside triphosphates (dNTPs) either by classical
triphosphorylation of nucleosides or by aqueous cross-coupling reactions of halogenated …
triphosphorylation of nucleosides or by aqueous cross-coupling reactions of halogenated …
Biological applications of xeno nucleic acids
K Morihiro, Y Kasahara, S Obika - Molecular BioSystems, 2017 - pubs.rsc.org
Biological applications of xeno nucleic acids - Molecular BioSystems (RSC Publishing) DOI:10.1039/C6MB00538A
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article Check for updates …
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article Check for updates …
Chemical methods for the modification of RNA
RNA is often considered as being the vector for the transmission of genetic information from
DNA to the protein synthesis machinery. However, besides translation RNA participates in a …
DNA to the protein synthesis machinery. However, besides translation RNA participates in a …