The plasma membrane of cells contains a diverse array of lipids that provide important
structural and biological features. Glycolipids are typically a minor component of the cell …

Due to the relevant biological role of sphingosines, ceramides and glycosyl ceramides, and
the increasing demand of these compounds for biological evaluations, developing methods …

Nature utilizes simple C2 and C3 building blocks, such as dihydroxyacetone phosphate
(DHAP), phosphoenolpyruvate (PEP), and the “active aldehyde” in various enzyme …

This study demonstrates the first formal asymmetric trans-dihydroxylation and trans-
aminohydroxylation of α, β-unsaturated aldehydes in an organocatalytic multibond forming …

The highly diastereoselective anti-aminohydroxylation of α, β-unsaturated esters,
viaconjugate addition of lithium (S)-N-benzyl-N-(α-methylbenzyl) amide and subsequent in …

The phytosphingosine-containing α-galactosylceramides (α-GalCers), KRN7000 and OCH,
have been shown to activate NKT cells via interaction with CD1d, a member of the CD1 …

Two variations of the Overman rearrangement have been developed for the highly selective
synthesis of anti-vicinal amino alcohol natural products. A MOM ether-directed palladium (II) …

The l-and d-threonine aldolase catalyzed formation of γ-halogenated and long-chain l-and d-
3-alkylserine-derivatives 1–12, respectively, was shown starting from glycine and …

An efficient methodology for the synthesis of sphingoid-type bases is reported. It involves the
stereoselective addition of a racemic 3-alkoxy allenylzinc to enantiopure N-tert-butylsulfinyl …

Ceramides are a complex group of lipids that has gained much attention as cell signaling
molecules and skin barrier constituents. In the skin, these sphingolipids form a major part of …