Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Diabetes mellitus is characterized by elevated levels of blood glucose and is ultimately
caused by insufficient insulin production from pancreatic beta cells. Different research …

Human embryonic stem cell-derived β cells (SC-β cells) hold great promise for treatment of
diabetes, yet how to achieve functional maturation and protect them against metabolic …

Human monogenic diabetes, caused by mutations in genes involved in beta cell
development and function, has been a challenge to study because multiple mouse models …

Background: Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder. The
aim of the present investigation was to identify gene signature specific to T2DM. Methods …

Pancreatic β-cells are the only source of insulin. Disturbances in β-cell development or
function may thus result in insulin deficiency or excess, presenting as hyper-or …

Generation of skeletal muscle cells with human pluripotent stem cells (hPSCs) opens new
avenues for deciphering essential, but poorly understood aspects of transcriptional …

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia as a
result of progressive loss of pancreatic β cells, which could lead to several debilitating …

Diabetes is characterized by elevated levels of blood glucose as a result of insufficient
production of insulin from loss or dysfunction of pancreatic islet β‐cells. Here, we review …

Genome-wide association studies (GWAS) have identified over 400 signals robustly
associated with risk for type 2 diabetes (T2D). At the vast majority of these loci, the lead …