Although antimicrobial resistance is an increasingly significant public health concern, there
have only been two new classes of antibiotics approved for human use since the 1960s …

The advantages of targeted therapy have motivated many efforts to find distinguishing
features between the molecular cell surface landscapes of diseased and normal cells …

Atomic detail simulations are starting to reveal how flexible polypeptides interact with fluid
lipid bilayers. These insights are transforming our understanding of one of the fundamental …

Breast cancer is the first malignant tumor in women, and its incidence is also increasing year
by year. Chemotherapy is one of the standard therapies for breast cancer, but the resistance …

Mitochondrial dysfunction is implicated in nine of the ten leading causes of death in the US,
yet there are no FDA-approved therapeutics to treat it. Synthetic mitochondria-targeted …

Membrane‐lytic peptides offer broad synthetic flexibilities and design potential to the arsenal
of anticancer therapeutics, which can be limited by cytotoxicity to noncancerous cells and …

Abstract The pH-Low Insertion Peptide (pHLIP) has emerged as an important tool for
targeting cancer cells; it has been assumed that its targeting mechanism depends solely on …

The pH-low insertion peptides (pHLIP) are pH-dependent membrane inserting peptides,
whose function depends on the cell microenvironment acidity. Several peptide variants have …

Purpose Acidity can be a useful alternative biomarker for the targeting of metabolically active
cells in certain diseased tissues, as in acute inflammation or aggressive tumors. We …

Accurate quantitative estimates of protein-membrane interactions are critical to studies of
membrane proteins. Here, we demonstrate that thermodynamic analyses based on current …