The human eye is a complex organ with unique anatomy and physiology that restricts the
delivery of drugs to target ocular tissues/sites. Recent advances in the field of pharmacy …

The delivery of drugs that target ocular tissues is challenging due to the physiological
barriers of the eye like tear dilution, nasolacrimal drainage, blinking, tear turnover rate and …

Highlights•A guideline for the development of ophthalmic in situ gelling systems is
proposed.•Gelation, gelation kinetics and rheological characterization methods are …

Achieving drug delivery at the ocular level encounters many challenges and obstacles. In
situ gelling delivery systems are now widely used for topical ocular administration and …

Ocular drug delivery is constrained by anatomical and physiological barriers, necessitating
innovative solutions for effective therapy. Natural polymers like hyaluronic acid, chitosan …

The current article mainly highlights mucoadhesive drug delivery with merits like the
prolonged holding time at the action site and also provides a controlled rate of drug release …

Objective (s): Ketotifen fumarate (KF) is a selective and noncompetitive histamine antagonist
(H1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and …

Eye is the most complicated and sophisticated organ of the body, so it is important that give
the especial attention to the eye diseases. For eye diseases various drug delivery system …

Eye being a unique and complex organ the access of exogenous substances to the ocular
tissues are restricted by its physiology and defense mechanism. Thus the delivery of …

Chapter 1: Ocular Pharmacokinetics Page 1 3 Chapter 1 Ocular Pharmacokinetics In general,
ocular pharmacokinetics have two routes, permeation and direct delivery [1–7]. • Permeation …