[HTML][HTML] Senescence in mesenchymal stem cells: functional alterations, molecular mechanisms, and rejuvenation strategies

J Liu, Y Ding, Z Liu, X Liang - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and
differentiation. There is increasing evidence of the therapeutic value of MSCs in various …

[HTML][HTML] Tendon injuries: Basic science and new repair proposals

F Wu, M Nerlich, D Docheva - EFORT open reviews, 2017 - eor.bioscientifica.com
Tendons connect muscles to bones, ensuring joint movement. With advanced age, tendons
become more prone to degeneration followed by injuries. Tendon repair often requires …

[HTML][HTML] Impact of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem/stromal cells

OS Beane, VC Fonseca, LL Cooper, G Koren… - PloS one, 2014 - journals.plos.org
Mesenchymal stem/stromal cells (MSCs) are promising cell sources for regenerative
therapies due to their multipotency and ready availability, but their application can be …

Characterization of bone marrow-derived mesenchymal stem cells in aging

N Baker, LB Boyette, RS Tuan - Bone, 2015 - Elsevier
Adult mesenchymal stem cells are a resource for autologous and allogeneic cell therapies
for immune-modulation and regenerative medicine. However, patients most in need of such …

The influence of aging on the regenerative potential of human adipose derived mesenchymal stem cells

M Marędziak, K Marycz, KA Tomaszewski… - Stem cells …, 2016 - Wiley Online Library
Tissue regeneration using human adipose derived mesenchymal stem cells (hASCs) has
significant potential as a novel treatment for many degenerative bone and joint diseases …

Human miR‐221/222 in physiological and atherosclerotic vascular remodeling

DA Chistiakov, IA Sobenin, AN Orekhov… - BioMed research …, 2015 - Wiley Online Library
A cluster of miR‐221/222 is a key player in vascular biology through exhibiting its effects on
vascular smooth muscle cells (VSMCs) and endothelial cells (ECs). These miRNAs …

MicroRNAs linking inflamm-aging, cellular senescence and cancer

F Olivieri, MR Rippo, V Monsurrò, S Salvioli… - Ageing research …, 2013 - Elsevier
Epidemiological and experimental data demonstrate a strong correlation between age-
related chronic inflammation (inflamm-aging) and cancer development. However, a …

[HTML][HTML] Epigenetic dysregulation in mesenchymal stem cell aging and spontaneous differentiation

Z Li, C Liu, Z Xie, P Song, RCH Zhao, L Guo, Z Liu… - PloS one, 2011 - journals.plos.org
Background Mesenchymal stem cells (MSCs) hold great promise for the treatment of difficult
diseases. As MSCs represent a rare cell population, ex vivo expansion of MSCs is …

Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration

J Kohler, C Popov, B Klotz, P Alberton, WC Prall… - Aging cell, 2013 - Wiley Online Library
Although the link between altered stem cell properties and tissue aging has been
recognized, the molecular and cellular processes of tendon aging have not been elucidated …

Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model

J Carlos Sepúlveda, M Tomé… - Stem …, 2014 - academic.oup.com
Mesenchymal stem cells (MSCs) possess unique paracrine and immunosuppressive
properties, which make them useful candidates for cellular therapy. Here, we address how …