Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Modeling the dynamics of wave propagation in human ventricular tissue and studying wave
stability require models that reproduce realistic characteristics in tissue. We present a …

Computational models of electrical activity and calcium signaling in cardiac myocytes are
important tools for understanding physiology. The sensitivity of these models to changes in …

Functional intercellular coupling has been demonstrated among networks of cardiac
fibroblasts, as well as between fibroblasts and atrial or ventricular myocytes. In this study, the …

In this manuscript we review the state of cardiac cell modelling in the context of international
initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim …

Across individuals within a population, several levels of variability are observed, from the
differential expression of ion channels at the molecular level, to the various action potential …

Acute myocardial ischemia is one of the main causes of sudden cardiac death. The
mechanisms have been investigated primarily in experimental and computational studies …

The beating of the heart is a synchronized contraction of muscle cells (myocytes) that is
triggered by a periodic sequence of electrical waves (action potentials) originating in the …

A normal heartbeat is orchestrated by the stable propagation of an excitation wave that
produces an orderly contraction. In contrast, wave turbulence in the ventricles, clinically …