Recent insights into microbial triggers of interleukin-10 production in the host and the impact on infectious disease pathogenesis
Since its initial description as a Th2-cytokine antagonistic to interferon-alpha and
granulocyte-macrophage colony-stimulating factor, many studies have shown various anti …
granulocyte-macrophage colony-stimulating factor, many studies have shown various anti …
[HTML][HTML] Experimental Validation of Multi-Epitope Peptides Including Promising MHC Class I- and II-Restricted Epitopes of Four Known Leishmania infantum Proteins
M Agallou, E Athanasiou, O Koutsoni… - Frontiers in …, 2014 - frontiersin.org
Leishmaniasis is a significant worldwide health problem for which no vaccine exists.
Activation of CD4+ and CD8+ T cells is crucial for the generation of protective immunity …
Activation of CD4+ and CD8+ T cells is crucial for the generation of protective immunity …
[HTML][HTML] Leishmania Eukaryotic Initiation Factor (LeIF) Inhibits Parasite Growth in Murine Macrophages
O Koutsoni, M Barhoumi, I Guizani, E Dotsika - PloS one, 2014 - journals.plos.org
The leishmaniases constitute neglected global public health problems that require adequate
control measures, prophylactic clinical vaccines and effective and non-toxic drug treatments …
control measures, prophylactic clinical vaccines and effective and non-toxic drug treatments …
[HTML][HTML] Identification of Immunoreactive Leishmania infantum Protein Antigens to Asymptomatic Dog Sera through Combined Immunoproteomics and Bioinformatics …
Leishmania infantum is the etiologic agent of zoonotic visceral leishmaniasis (VL) in
countries in the Mediterranean basin, where dogs are the domestic reservoirs and represent …
countries in the Mediterranean basin, where dogs are the domestic reservoirs and represent …
Bioinformatics analyses of immunogenic T-cell epitopes of LeIF and PpSP15 proteins from Leishmania major and sand fly saliva used as model antigens for the …
A Bordbar, KP Bagheri, S Ebrahimi, P Parvizi - Infection, Genetics and …, 2020 - Elsevier
Leishmaniasis is caused by protozoan parasites belonging to 20 Leishmania species. This
infectious disease is transmitted by bites of infected phlebotomine sandflies, and is …
infectious disease is transmitted by bites of infected phlebotomine sandflies, and is …
The steroid derivative 6-aminocholestanol inhibits the DEAD-box helicase eIF4A (LieIF4A) from the Trypanosomatid parasite Leishmania by perturbing the RNA and …
YZ Abdelkrim, E Harigua-Souiai, M Barhoumi… - Molecular and …, 2018 - Elsevier
The antifungal agent 6-aminocholestanol targets the production of ergosterol, which is the
principle sterol in many fungi and protozoans; ergosterol serves many of the same roles as …
principle sterol in many fungi and protozoans; ergosterol serves many of the same roles as …
Codelivery of DNA vaccination encoding LeIF gene and IL‐12 increases protection against Leishmania major infection in BALB/c mice
Previous studies have shown that Leishmania elongation initiation factor (Le IF) antigen
causes a partial immunity against leishmaniasis. The antigen develops type I immunity by …
causes a partial immunity against leishmaniasis. The antigen develops type I immunity by …
Immunogenicity and efficacy of a bivalent DNA vaccine containing LeIF and TSA genes against murine cutaneous leishmaniasis
There is no effective vaccine for the prevention and elimination of leishmaniasis. For this
reason, we assessed the protective effects of DNA vaccines containing Le IF, TSA genes …
reason, we assessed the protective effects of DNA vaccines containing Le IF, TSA genes …
[HTML][HTML] Immunomodulatory Effects of Four Leishmania infantum Potentially Excreted/Secreted Proteins on Human Dendritic Cells Differentiation and Maturation
W Markikou-Ouni, S Drini, N Bahi-Jaber, M Chenik… - PloS one, 2015 - journals.plos.org
Leishmania parasites and some molecules they secrete are known to modulate innate
immune responses through effects on dendritic cells (DCs) and macrophages. Here, we …
immune responses through effects on dendritic cells (DCs) and macrophages. Here, we …
[HTML][HTML] Enzymatic and molecular characterization of anti-leishmania molecules that differently target leishmania and mammalian eIF4A proteins, LieIF4A and …
YZ Abdelkrim, E Harigua-Souiai, I Bassoumi-Jamoussi… - Molecules, 2022 - mdpi.com
Previous investigations of the Leishmania infantum eIF4A-like protein (LieIF4A) as a
potential drug target delivered cholestanol derivatives inhibitors. Here, we investigated the …
potential drug target delivered cholestanol derivatives inhibitors. Here, we investigated the …