Small molecule chemical probes are valuable tools for interrogating protein biological
functions and relevance as a therapeutic target. Rigorous validation of chemical probe …

There are only a few platforms that integrate multiple omics data types, bioinformatics tools,
and interfaces for integrative analyses and visualization that do not require programming …

Chemical-induced gene expression profiles provide critical information of chemicals in a
biological system, thus offering new opportunities for drug discovery. Despite their success …

Motivation Identifying mechanism of actions (MoA) of novel compounds is crucial in drug
discovery. Careful understanding of MoA can avoid potential side effects of drug candidates …

Drug repositioning aims to discover novel clinical benefits of existing drugs, is an effective
way to develop drugs for complex diseases such as cancer and may facilitate the process of …

Motivation Aberrant cell signaling is known to drive progression of cancer and many other
diseases. The study of signaling pathways within cells is central to identifying drugs that …

Identification of the mechanism of action (MoA) of a small molecule which causes
pharmacological effects on cellular networks governing gene expression levels is an …

Resistance to cancer therapy seems to be inevitable in many clinical settings. Increasing
evidence has suggested that treatment-elicited molecular responses may play a role in …

Studying changes in gene expression caused by genetic and chemical perturbations in cells
can allow scientists to learn more about genetic diseases, such as cancer, and the cellular …