Misguided attack of immune systems on self-tissue or multifactorial uncontrolled
inflammation is capable of causing inflammatory diseases. Neutrophils play a critical role in …

The critical role of tumor microenvironment (TME) in tumor initiation and development has
been well-recognized after more than a century of studies. Numerous therapeutic …

The polarization of tumor-associated macrophages (TAMs) from M2 to M1 phenotype
demonstrates great potential for remodeling the immunosuppressive tumor …

Understanding the mechanism and progression of neutrophil-involved diseases (eg, acute
inflammation) is of great importance. However, current available analytical methods neither …

The prognosis in cases of pancreatic ductal adenocarcinoma (PDAC) with current treatment
modalities is poor owing to the highly desmoplastic tumor microenvironment (TME). Herein …

The local microenvironment where tumors develop can shape cancer progression and
therapeutic outcome. Emerging evidence demonstrate that the efficacy of immune …

The immune resistance of tumor microenvironment (TME) causes immune checkpoint
blockade therapy inefficient to hepatocellular carcinoma (HCC). Emerging strategies of …

Pancreatic cancer remains one of the deadliest cancers with extremely high mortality rate,
and the number of cases is expected to steadily increase with time. Pancreatic cancer is …

Despite significant treatment efforts, pancreatic ductal adenocarcinoma (PDAC), the
deadliest solid tumor, is still incurable in the preclinical stages due to multifacet stroma …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a five-year
survival rate of only 9%. PDAC is characterized by a dense, fibrotic stroma composed of …