The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR)
are crucial to our understanding of immunity and the harnessing of T cells therapeutically. A …

This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …

The initiation of T cell antigen receptor signaling is a key step that can result in T cell
activation and the orchestration of an adaptive immune response. Early events in T cell …

The TCR can detect subtle differences in the strength of interaction with peptide/MHC ligand
and transmit this information to influence downstream events in T cell responses …

Engineered T cells that express chimeric antigen receptors (CARs) have transformed the
treatment of haematological cancers. CARs combine the tumour-antigen-binding function of …

Chimeric antigen receptor (CAR)–modified T cell therapy is effective in treating lymphomas,
leukemias, and multiple myeloma in which the tumor cells express high amounts of target …

Simple Summary CD3 complex provides the first signal sensed by the TCR of the
lymphocyte to trigger its activation. Thus, it becomes a very attractive receptor to determine …

The series of events leading to T‐cell activation following antigen recognition has been
extensively investigated. Although the exact mechanisms of ligand binding and transmission …

The T‐cell receptor (TCR)–CD3 complex, expressed on T cells, determines the outcome of a
T‐cell response. It consists of the TCR‐αβ heterodimer and the non‐covalently associated …

T cell receptor (TCR) gene therapy provides patients with autologous T cells that are
genetically engineered with TCRαβ chains and constitutes a promising approach for the …