Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise
transformation from healthy epithelium to premalignant dysplasia to invasive neoplasia …

Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with its
incidence rising steeply. Immunosuppression is a well-established risk factor for cSCC, and …

Melanoma skin cancer is derived from skin melanocytes and has a high risk of metastatic
spread. Many clinical attributes and risk factors associated with melanoma have been well …

Abstract The Rotterdam Study is a population-based cohort study, started in 1990 in the
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …

Simple Summary The performance of genome-wide association studies with high-density
single-nucleotide polymorphism panels and next-generation sequencing is a robust …

Invasive cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in
white populations, accounting for 20% of all cutaneous malignancies. Overall, cSCC mostly …

Survivors of childhood cancer are at increased risk for subsequent cancers attributable to
the late effects of radiotherapy and other treatment exposures; thus, further understanding of …

The antagonistic pleiotropy hypothesis posits that natural selection for pleiotropic mutations
that confer earlier or more reproduction but impair the post-reproductive life causes aging …

Background Trichorhinophalangeal syndrome type 1 (TPRS1) expression has been found to
be highly sensitive and specific for breast carcinomas. The frequency of TRPS1 expression …

PURPOSE Chemotherapeutic exposures are associated with subsequent malignant
neoplasm (SMN) risk. The role of genetic susceptibility in chemotherapy-related SMNs …