[HTML][HTML] Topoisomerase IB: a relaxing enzyme for stressed DNA
BC Soren, JB Dasari, A Ottaviani, F Iacovelli… - Cancer Drug …, 2020 - ncbi.nlm.nih.gov
DNA topoisomerase I enzymes relieve the torsional strain in DNA; they are essential for
fundamental molecular processes such as DNA replication, transcription, recombination …
fundamental molecular processes such as DNA replication, transcription, recombination …
Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states
DT Takahashi, D Gadelle, K Agama, E Kiselev… - Nature …, 2022 - nature.com
Eukaryotic topoisomerases I (TOP1) are ubiquitous enzymes removing DNA torsional stress.
However, there is little data concerning the three-dimensional structure of TOP1 in the …
However, there is little data concerning the three-dimensional structure of TOP1 in the …
A tale of topoisomerases and the knotty genetic material in the backdrop of Plasmodium biology
The untangling or overwinding of genetic material is an inevitable part of DNA replication,
repair, recombination, and transcription. Topoisomerases belong to a conserved enzyme …
repair, recombination, and transcription. Topoisomerases belong to a conserved enzyme …
DNA topoisomerase I domain interactions impact enzyme activity and sensitivity to camptothecin
CM Wright, M Van Der Merwe, AH DeBrot… - Journal of Biological …, 2015 - ASBMB
During processes such as DNA replication and transcription, DNA topoisomerase I (Top1)
catalyzes the relaxation of DNA supercoils. The nuclear enzyme is also the cellular target of …
catalyzes the relaxation of DNA supercoils. The nuclear enzyme is also the cellular target of …
Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein–DNA binding site
Human topoisomerase 1B has been simulated covalently bound to a negatively supercoiled
DNA minicircle, and its behavior compared to the enzyme bound to a simple linear DNA …
DNA minicircle, and its behavior compared to the enzyme bound to a simple linear DNA …
Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico
C Tesauro, B Morozzo della Rocca, A Ottaviani… - Molecular cancer, 2013 - Springer
Background DNA topoisomerases are key enzymes that modulate the topological state of
DNA through the breaking and rejoining of DNA strands. Human topoisomerase IB can be …
DNA through the breaking and rejoining of DNA strands. Human topoisomerase IB can be …
In vitro and in silico characterization of an antimalarial compound with antitumor activity targeting human DNA topoisomerase IB
BC Soren, J Babu Dasari, A Ottaviani… - International Journal of …, 2021 - mdpi.com
Human DNA topoisomerase IB controls the topological state of supercoiled DNA through a
complex catalytic cycle that consists of cleavage and religation reactions, allowing the …
complex catalytic cycle that consists of cleavage and religation reactions, allowing the …
Theoretical and Experimental Studies of New Modified Isoflavonoids as Potential Inhibitors of Topoisomerase I from Plasmodium falciparum
WA Cortopassi, J Penna-Coutinho, ACC Aguiar… - PloS one, 2014 - journals.plos.org
DNA topoisomerase I from Plasmodium falciparum (Pf TopoI), a potential selective target for
chemotherapy and drug development against malaria, is used here, together with human …
chemotherapy and drug development against malaria, is used here, together with human …
The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation
I D'Annessa, C Tesauro, Z Wang, B Arnò… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Human topoisomerase 1B, the unique target of the natural anticancer compound
camptothecin, catalyzes the unwinding of supercoiled DNA by introducing transient single …
camptothecin, catalyzes the unwinding of supercoiled DNA by introducing transient single …
Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain …
Z Wang, I D'Annessa, C Tesauro, S Croce… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Human topoisomerase 1B controls the topological state of supercoiled DNA allowing the
progression of fundamental cellular processes. The enzyme, which is the unique molecular …
progression of fundamental cellular processes. The enzyme, which is the unique molecular …