Gestation-specific changes in the anatomy and physiology of healthy pregnant women: an extended repository of model parameters for physiologically based …
Background In the past years, several repositories for anatomical and physiological
parameters required for physiologically based pharmacokinetic modeling in pregnant …
parameters required for physiologically based pharmacokinetic modeling in pregnant …
Utilization of physiologically based pharmacokinetic modeling in clinical pharmacology and therapeutics: an overview
C Perry, G Davis, TM Conner, T Zhang - Current Pharmacology Reports, 2020 - Springer
The purpose of this review was to assess the advancement of applications for
physiologically based pharmacokinetic (PBPK) modeling in various therapeutic areas. We …
physiologically based pharmacokinetic (PBPK) modeling in various therapeutic areas. We …
Development of a whole-body physiologically based pharmacokinetic approach to assess the pharmacokinetics of drugs in elderly individuals
JF Schlender, M Meyer, K Thelen, M Krauss… - Clinical …, 2016 - Springer
Background Because of the vulnerability and frailty of elderly adults, clinical drug
development has traditionally been biased towards young and middle-aged adults. Recent …
development has traditionally been biased towards young and middle-aged adults. Recent …
A physiologically based pharmacokinetic model for pregnant women to predict the pharmacokinetics of drugs metabolized via several enzymatic pathways
Background Physiologically based pharmacokinetic modeling is considered a valuable tool
for predicting pharmacokinetic changes in pregnancy to subsequently guide in-vivo …
for predicting pharmacokinetic changes in pregnancy to subsequently guide in-vivo …
Physiologically based pharmacokinetic modeling in pregnancy: a systematic review of published models
During recent years there has been a surge in developing and applying physiologically
based pharmacokinetic (PBPK) models in pregnant women to better understand and predict …
based pharmacokinetic (PBPK) models in pregnant women to better understand and predict …
Challenges associated with applying physiologically based pharmacokinetic modeling for public health decision-making
YM Tan, RR Worley, JA Leonard… - Toxicological …, 2018 - academic.oup.com
The development and application of physiologically based pharmacokinetic (PBPK) models
in chemical toxicology have grown steadily since their emergence in the 1980s. However …
in chemical toxicology have grown steadily since their emergence in the 1980s. However …
Renal precision medicine in neonates and acute kidney injury: how to convert a cloud of creatinine observations to support clinical decisions
K Allegaert, A Smits, T Van Donge… - Frontiers in …, 2020 - frontiersin.org
Renal precision medicine in neonates is useful to support decision making on
pharmacotherapy, signal detection of adverse (drug) events, and individual prediction of …
pharmacotherapy, signal detection of adverse (drug) events, and individual prediction of …
Challenges Related to Acquisition of Physiological Data for Physiologically Based Pharmacokinetic (PBPK) Models in Postpartum, Lactating Women and Breastfed …
M Van Neste, A Bogaerts, N Nauwelaerts, J Macente… - Pharmaceutics, 2023 - mdpi.com
Physiologically based pharmacokinetic (PBPK) modelling is a bottom-up approach to predict
pharmacokinetics in specific populations based on population-specific and medicine …
pharmacokinetics in specific populations based on population-specific and medicine …
Preterm physiologically based pharmacokinetic model. Part II: applications of the model to predict drug pharmacokinetics in the preterm population
K Abduljalil, X Pan, A Pansari, M Jamei… - Clinical …, 2020 - Springer
Background Preterm neonates are usually not part of a traditional drug development
programme, however they are frequently administered medicines. Developing modelling …
programme, however they are frequently administered medicines. Developing modelling …
[HTML][HTML] PBPK model reporting template for chemical risk assessment applications
YM Tan, M Chan, A Chukwudebe, J Domoradzki… - Regulatory Toxicology …, 2020 - Elsevier
Physiologically-based pharmacokinetic (PBPK) modeling analysis does not stand on its own
for regulatory purposes but is a robust tool to support drug/chemical safety assessment …
for regulatory purposes but is a robust tool to support drug/chemical safety assessment …