Zebrafish as a model for obesity and diabetes

L Zang, LA Maddison, W Chen - Frontiers in cell and developmental …, 2018 - frontiersin.org
Obesity and diabetes now considered global epidemics. The prevalence rates of diabetes
are increasing in parallel with the rates of obesity and the strong connection between these …

Little fish, big data: zebrafish as a model for cardiovascular and metabolic disease

P Gut, S Reischauer, DYR Stainier… - Physiological …, 2017 - journals.physiology.org
The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

[HTML][HTML] Photoaging enhanced the adverse effects of polyamide microplastics on the growth, intestinal health, and lipid absorption in developing zebrafish

X Zhang, M Xia, J Zhao, Z Cao, W Zou, Q Zhou - Environment International, 2022 - Elsevier
The safety of microplastics (MPs) and associated health effects has been one of the major
concerns worldwide. However, the role of photoaging toward the risk of MPs in water …

Zebrafish embryonic lipidomic analysis reveals that the yolk cell is metabolically active in processing lipid

D Fraher, A Sanigorski, NA Mellett, PJ Meikle… - Cell reports, 2016 - cell.com
The role of lipids in providing energy and structural cellular components during vertebrate
development is poorly understood. To elucidate these roles further, we visualized lipid …

Maternal investment in fish oocytes and eggs: the molecular cargo and its contributions to fertility and early development

E Lubzens, J Bobe, G Young, CV Sullivan - Aquaculture, 2017 - Elsevier
The production of fertile eggs with the capacity to develop into larvae and subsequently into
marketable fish is centrally important to the aquaculture industry. This entails not only the …

Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish

K Stoletov, L Fang, SH Choi, K Hartvigsen… - Circulation …, 2009 - Am Heart Assoc
Lipid accumulation in arteries induces vascular inflammation and atherosclerosis, the major
cause of heart attack and stroke in humans. Extreme hyperlipidemia induced in mice and …

Ontogeny and nutritional control of adipogenesis in zebrafish (Danio rerio)

EJ Flynn, CM Trent, JF Rawls - Journal of lipid research, 2009 - ASBMB
The global obesity epidemic demands an improved understanding of the developmental
and environmental factors regulating fat storage. Adipocytes serve as major sites of fat …

Evolutionarily conserved gene family important for fat storage

B Kadereit, P Kumar, WJ Wang… - Proceedings of the …, 2008 - National Acad Sciences
The ability to store fat in the form of cytoplasmic triglyceride droplets is conserved from
Saccharomyces cerevisiae to humans. Although much is known regarding the composition …

Molecular nanoinformatics approach assessing the biocompatibility of biogenic silver nanoparticles with channelized intrinsic steatosis and apoptosis

PK Panda, P Kumari, P Patel, SK Samal, S Mishra… - Green …, 2022 - pubs.rsc.org
The developmental rapidity of nanotechnology poses higher risks of exposure to humans
and the environment through manufactured nanomaterials. The multitude of biological …

Zebrafish lipid metabolism: from mediating early patterning to the metabolism of dietary fat and cholesterol

JL Anderson, JD Carten, SA Farber - Methods in cell biology, 2011 - Elsevier
Lipids serve essential functions in cells as signaling molecules, membrane components,
and sources of energy. Defects in lipid metabolism are implicated in a number of pandemic …