DNA nanomaterial‐empowered surface engineering of extracellular vesicles

X Yao, D He, P Wei, Z Niu, H Chen, L Li… - Advanced …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are cell‐secreted biological nanoparticles that are critical
mediators of intercellular communication. They contain diverse bioactive components, which …

Tailored diagnostic tool for exosome detection utilizing DNA-based nanostructures

B Wang, X Tang, X Gao, S Xie, Y Pi, M Chen… - TrAC Trends in …, 2023 - Elsevier
Exosomes are membrane-bound nanovesicles secreted by all cell types and contain diverse
molecules. Detecting cancer-derived exosomes and their cargo, which are closely related to …

Fluorescence‐Amplified Origami Microneedle Device for Quantitatively Monitoring Blood Glucose

X Li, X Xu, K Wang, Y Chen, Y Zhang, Q Si… - Advanced …, 2023 - Wiley Online Library
Exploration of clinically acceptable blood glucose monitors has been engaging in the past
decades, yet the ability to quantitatively detect blood glucose in a painless, accurate, and …

Membrane Fusion‐Mediated Loading of Therapeutic siRNA into Exosome for Tissue‐Specific Application

M Xie, Y Wu, Y Zhang, R Lu, Z Zhai, Y Huang… - Advanced …, 2024 - Wiley Online Library
Tissue‐specific delivery of oligonucleotide therapeutics beyond the liver remains a key
challenge in nucleic acid drug development. To address this issue, exploiting exosomes as …

Encoded Fusion-Mediated MicroRNA Signature Profiling of Tumor-Derived Extracellular Vesicles for Pancreatic Cancer Diagnosis

J Feng, Y Shu, Y An, Q Niu, Q Fan, Y Lei… - Analytical …, 2023 - ACS Publications
MicroRNAs (miRNAs) in tumor-derived extracellular vesicles (tEVs) are important cancer
biomarkers for cancer screening and early diagnosis. Multiplex detection of miRNAs in tEVs …

DNA-Programmed Lipid Nanoreactors for Synthesis of Carbohydrate Mimetics by Fusion of Aqueous Sub-attoliter Compartments

X Tian, NA Risgaard, PMG Löffler… - Journal of the American …, 2023 - ACS Publications
Lipid nanoreactors are biomimetic reaction vessels (nanoreactors) that can host aqueous or
membrane-associated chemical and enzymatic reactions. Nanoreactors provide ultra …

Exosomal non-coding RNAs (ncRNAs) as potential biomarkers in tumor early diagnosis

J Chang, L Zhang, Z Li, C Qian, J Du - Biochimica et Biophysica Acta (BBA) …, 2024 - Elsevier
Exosomes, extracellular vesicles carrying a cargo rich in various non-coding RNAs
(ncRNAs), have emerged as crucial mediators of intercellular communication. Their stability …

DNA‐Based Nanomaterials for Analysis of Extracellular Vesicles

J Deng, C Liu, J Sun - Advanced Materials, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are cell‐derived nanovesicles comprising a myriad of molecular
cargo such as proteins and nucleic acids, playing essential roles in intercellular …

A multivalent dual lock-and-key system and its toehold-mediated orthogonal activation for highly specific strand displacement amplification

Q Song, C Li, Y Cheng, L Lan, R Cheng… - Sensors and Actuators B …, 2023 - Elsevier
DNA strand displacement reaction plays an essential role in dynamic DNA nanotechnology
and has proven powerful in DNA nano-computers and biosensors. However, the poor …

Programmable Nanostructures Based on Framework-DNA for Applications in Biosensing

B Liu, F Wang, J Chao - Sensors, 2023 - mdpi.com
DNA has been actively utilized as bricks to construct exquisite nanostructures due to their
unparalleled programmability. Particularly, nanostructures based on framework DNA (F …