In the last decades, coronaviruses have been a major threat to public health worldwide.
SARS-CoV-2 is the third known coronavirus that causes fatal respiratory diseases in …

Single-cell RNA sequencing (scRNA-seq) is a rich resource of cellular heterogeneity,
opening new avenues in the study of complex tissues. We introduce Cell Population …

Acute respiratory distress syndrome (ARDS) is triggered by various aetiological factors such
as trauma, sepsis and respiratory viruses including SARS-CoV-2 and influenza A virus …

The interferon (IFN) pathway plays an essential role in the innate immune response
following viral infections and subsequent shaping of adaptive immunity. Infections with …

Severe pathological damage caused by the influenza virus is one of the leading causes of
death. However, the prevention and control strategies for influenza virus infection have …

The murine infection model is a cornerstone for influenza virus research and includes
aspects such as disease pathogenesis, immunobiology, and vaccine and antiviral drug …

Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is necessary for viral
activation and infectivity. In humans and mice, members of the type II transmembrane …

Background Influenza A virus is a zoonotic pathogen that poses a major threat to human and
animal health. The severe course of influenza infection is not only influenced by viral …

The surface protein haemagglutinin (HA) of influenza A viruses (IAV) needs to be cleaved by
a host protease to become functional. Here, we investigated if IAV of the H10 subtype also …

Bleomycin (BLM)-induced pulmonary fibrosis is characterized by inflammation in the alveoli,
subsequent deposition of extracellular matrix (ECM) and myofibroblasts, and an impaired …