Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal‐like cells as pacemakers

RJ Lang, MA Tonta, BZ Zoltkowski… - The Journal of …, 2006 - Wiley Online Library
Pyeloureteric peristalsis has long been considered to be triggered by pacemaker atypical
smooth muscle cells (SMC) located in the proximal regions of the renal pelvis. However …

Identification of the cells underlying pacemaker activity in the guinea‐pig upper urinary tract

MF Klemm, B Exintaris, RJ Lang - The Journal of physiology, 1999 - Wiley Online Library
1 The varying profile of cell types along the muscle wall of the guinea‐pig upper urinary tract
was examined electrophysiologically, using intracellular microelectrodes, and …

Interstitial cell of Cajal‐like cells in the upper urinary tract

RJ Lang, MF Klemm - Journal of cellular and molecular …, 2005 - Wiley Online Library
Autorhythmicity in the upper urinary tract (UUT) has long been considered to arise in
specialized atypical smooth muscle cells (SMC) predominately situated in the most proximal …

Spontaneous electrical and Ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of Cajal‐like cells of mouse renal pelvis

RJ Lang, H Hashitani, MA Tonta… - The Journal of …, 2007 - Wiley Online Library
Electrical rhythmicity in the renal pelvis provides the fundamental drive for the peristaltic
contractions that propel urine from the kidney to bladder for storage until micturition …

Electrical basis of peristalsis in the mammalian upper urinary tract

RJ Lang, B Exintaris, ME Teele… - Clinical and …, 1998 - Wiley Online Library
Peristalsis in the mammalian upper urinary tract (UUT) is mostly myogenic in origin,
originating predominately in the proximal pelvicalyceal regions of the renal pelvis, an area …

Ion channel modulators and urinary tract function

AF Brading, KL Brain - Urinary Tract, 2011 - Springer
The membrane potential fulfils an important role in initiating smooth muscle contraction,
through its depolarization and the subsequent influx of Ca 2+ through voltage-gated Ca 2+ …

Ureteral motility

F Osman, I Romics, P Nyírády, E Monos… - Acta Physiologica …, 2009 - akjournals.com
The pyeloureteral function is to transport urine from the kidneys into the ureter toward the
urinary bladder for storage until micturition. A set of mechanisms collaborates to achieve this …

Pacemaker mechanisms driving pyeloureteric peristalsis: modulatory role of interstitial cells

RJ Lang, H Hashitani - Smooth Muscle Spontaneous Activity: Physiological …, 2019 - Springer
The peristaltic pressure waves in the renal pelvis that propel urine expressed by the kidney
into the ureter towards the bladder have long been considered to be 'myogenic', being little …

Spontaneous electrical and Ca2+ signals in the mouse renal pelvis that drive pyeloureteric peristalsis

RJ Lang, H Hashitani, MA Tonta… - Clinical and …, 2010 - Wiley Online Library
Peristalsis in the smooth muscle cell (SMC) wall of the pyeloureteric system is unique in
physiology in that the primary pacemaker resides in a population of atypical SMCs situated …

Autonomic and sensory nerve modulation of peristalsis in the upper urinary tract

MJ Nguyen, R Higashi, K Ohta, KI Nakamura… - Autonomic …, 2016 - Elsevier
The primary function of the upper urinary tract is to propel urine and various water-soluble
toxic compounds from the kidneys to the bladder for storage and evacuation to maintain …