Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …

Head and neck squamous cell carcinomas (HNSCCs) are highly aggressive, multi-factorial
tumors in the upper aerodigestive tract affecting more than half a million patients worldwide …

Neutrophils and polymorphonucler myeloid-derived suppressor cells (PMN-MDSC) share
origin and many morphological and phenotypic features. However, they have different …

Metastasis is a distinct stage of cancer progression that requires the development of
angiogenic blood vessels serving as conduits for tumor cell dissemination. An accumulated …

Expansion of myeloid cells associated with solid tumor development is a key contributor to
neoplastic progression. Despite their clinical relevance, the mechanisms controlling myeloid …

While T-cell responses to cancer immunotherapy have been avidly studied, long-lived
memory has been poorly characterized. In a cohort of metastatic melanoma survivors with …

Cancer can involve non-resolving, persistent inflammation where varying numbers of tumor-
associated macrophages (TAMs) infiltrate and adopt different activation states between anti …

Background: Pancreatic cancer is one of the cancers where anti-PD-L1/PD-1
immunotherapy has been unsuccessful. What confers pancreatic cancer resistance to …

Our current understanding of human tumor-resident myeloid cells is, for the most part, based
on a large body of work in murine models or studies enumerating myeloid cells in patient …