RNA 5-Methylcytosine Modification: Regulatory Molecules, Biological Functions, and Human Diseases

Y Lu, L Yang, Q Feng, Y Liu, X Sun, D Liu… - Genomics …, 2024 - academic.oup.com
RNA methylation modifications influence gene expression, and disruptions of these
processes are often associated with various human diseases. The common RNA …

Decoding the ribosome's hidden language: rRNA modifications as key players in cancer dynamics and targeted therapies

L Cui, J Zheng, Y Lin, P Lin, Y Lu… - Clinical and …, 2024 - Wiley Online Library
Ribosomal RNA (rRNA) modifications, essential components of ribosome structure and
function, significantly impact cellular proteomics and cancer biology. These chemical …

Niujiao Dihuang Jiedu decoction promotes SLC7A11 m5C methylation modification against ferroptosis in acute-on-chronic liver failure

L Huang, J Liu, Y Jin, Y Qiu, X Qin, S Wu, D Chen… - Phytomedicine, 2024 - Elsevier
Background Acute-on-chronic liver failure (ACLF) constitutes a prevalent manifestation of
liver failure within clinical settings. This condition manifests swiftly and is characterized by an …

RNA Methyltransferase NSUN5 Promotes Esophageal Cancer via 5‐Methylcytosine Modification of METTL1

Y Cui, Z Hu, C Zhang - Molecular Carcinogenesis, 2024 - Wiley Online Library
Aberrant RNA modifications can drive carcinogenic transformation and tumor progression,
with 5‐methylcytosine (m5C) emerging as one of the predominant RNA modifications in …

Unveiling the role of RNA methylation in glioma: Mechanisms, prognostic biomarkers, and therapeutic targets

Q Xu, C Yang, L Wang, J Zhou - Cellular Signalling, 2024 - Elsevier
Gliomas, the most prevalent malignant brain tumors in the central nervous system, are
marked by rapid growth, high recurrence rates, and poor prognosis. Glioblastoma (GBM) …

[HTML][HTML] NSUN5 promotes tumorigenic phenotypes through the WNT signaling pathway and immunosuppression of CD8+ T cells in gastric cancer

S Liu, Y Liu, Y Zhou, G Xia, H Liu, Y Zeng, Z Pei, J Cao… - Cellular …, 2024 - Elsevier
NSUN5, a key member of the M5C methylation family, plays a significant role in fundamental
biological processes like cell proliferation and differentiation. However, its specific function …

[HTML][HTML] Diagnostic and predictive values of m5C‑associated genes in idiopathic pulmonary fibrosis

L Tian, W Song, J Wu, Y Lan… - Molecular Medicine …, 2025 - spandidos-publications.com
In patients with idiopathic pulmonary fibrosis (IPF), the role of 5‑methylcytosine (m5C)‑
associated genes in the pathogenesis and development of the disease remains unclear …