Osteosarcoma is the most common primary malignant bone tumour in children and
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …

Osteosarcoma (OS), the most common type of primary malignant bone tumor, is defined by
the presence of malignant mesenchymal cells producing osteoid or immature bone. The …

Abstract Learning Objectives After completing this course, the reader will be able to: Discuss
etiologic and biologic factors in osteosarcoma. Select the appropriate diagnostic work-up for …

Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in
children and adolescents relative to other age groups. The etiology of this often aggressive …

In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and
some related tumors published since our book appeared in 1994 [1] will be presented and …

This review summarizes reports of recurrent DNA sequence copy number amplifications in
human neoplasms detected by comparative genomic hybridization. Some of the …

Osteosarcoma is the most common primary malignancy of bone, typically presenting in the
first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients …

Osteosarcoma is a devastating but rare disease, whose study has illuminated both the basic
biology and clinical management of cancer over the past 30 years. These contributions have …

Low-grade osteosarcoma is a rare malignancy that may be subdivided into two main
subgroups on the basis of location in relation to the bone cortex, that is, parosteal …

In some types of cancer, telomere length is maintained by the alternative lengthening of
telomeres (ALT) mechanism. In many ALT cancers, the α‐thalassemia/mental retardation …