Metabolic reprogramming is a hallmark of cancer and allows tumour cells to meet the
increased energy demands required for rapid proliferation, invasion, and metastasis …

Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

NAFLD affects a large proportion of the US population and its incidence and prevalence are
increasing to epidemic proportions around the world. As with other liver diseases that cause …

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …

Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated
in small amounts during the body's metabolic reactions and can react with and damage …

BACKGROUND/AIMS: Portal vein thrombosis in patients with liver cirrhosis is usually
associated to hepatocellular carcinoma. Clinical presentation of non-neoplastic portal vein …

Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound
hepatocellular dysfunction for which targeted treatments are urgently needed. Identification …

S-adenosyl-l-methionine (SAMe; AdoMet) is an important, metabolically pleiotropic molecule
that participates in multiple cellular reactions as the precursor for the synthesis of glutathione …

Hepatocellular carcinoma (HCC) is a deadly tumour whose causative agents are generally
well known, but whose pathogenesis remains poorly understood. Nevertheless, key genetic …