Microglia are the resident brain macrophages and they have been traditionally studied as
orchestrators of the brain inflammatory response during infections and disease. In addition …

Vesicular stomatitis virus (VSV), a negative-strand RNA virus of the Vesiculovirus genus, has
demonstrated encouraging anti-neoplastic activity across multiple human cancer types. VSV …

Background Breast cancer is the most common malignant disease amongst Western
women. The lack of treatment options for patients with chemotherapy-resistant or recurrent …

Oncolytic viruses are known to stimulate the antitumor immune response by specifically
replicating in tumor cells. This is believed to be an important aspect of the durable …

Immunotherapy is at the cutting edge of modern cancer treatment. Innovative medicines
have been developed with varying degrees of success that target all aspects of tumor …

This introductory paper gathers general considerations on the biosafety of virus-derived
vectors that are used in human gene therapy and/or vaccination. The importance to assess …

Glioblastoma (GBM) is an obligatory lethal brain tumor with a median survival, even with the
best standard of care therapy, of less than 20 months. In light of this fact, the evaluation of …

The worldwide burden of cancers is increasing at a very high rate, including the aggressive
and resistant forms of cancers. Certain levels of breakthrough have been achieved with the …

Anti-tumor immunity can eliminate existing cancer cells and also maintain a constant
surveillance against possible relapse. Such an antigen-specific adaptive response begins …

Oncolytic strains of vaccinia virus are currently in clinical development with clear evidence of
safety and promising signs of efficacy. Addition of therapeutic genes to the viral genome may …