It is well established that multifactorial drug resistance hinders successful cancer treatment.
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …

Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumour in humans and has a very poor prognosis. The existing treatments have had limited …

Simple Summary This review describes in a very detailed and exhaustive approach the
literature of these last 20 years on glioblastoma targeted therapies in Phases II-IV of 257 …

Simple Summary Glioblastoma is the most common malignant brain tumor associated with a
poor prognosis, with a median survival of 14 months. Despite initial treatment with surgery …

Background Arachidonic acid (AA) metabolic enzymes including cyclooxygenase-2 (COX-
2), microsomal prostaglandin E synthase-1 (mPGES-1) and cytochrome P450 (CYP) 4A11 …

Glioblastoma Multiforme (GBM) is one the most common intracranial tumors discovered by
Burns (1800) and Abernethy (1804) based on gross morphology of the autopsied material …

From all central nervous system tumors, gliomas are the most common. Nowadays,
researchers are looking for more efficient treatments for these tumors, as well as ways for …

Glioblastoma (GBM) is the most frequent and aggressive primary central nervous system
tumor. Surgery followed by radiotherapy and chemotherapy with alkylating agents …

The receptor tyrosine kinase AXL (RTK-AXL) is implicated in therapy resistance and tumor
progression in glioblastoma multiforme (GBM). Here, we investigated therapy-induced …

Simple Summary Childhood glioblastoma is an aggressive brain tumor in children that has a
very poor prognosis. Standard therapy includes surgery, irradiation and chemotherapy with …