Several challenges to current views of thalamocortical processing are offered here.
Glutamatergic pathways in thalamus and cortex are divided into two distinct classes: driver …

Migraine is a common, multifactorial, disabling, recurrent, hereditary neurovascular
headache disorder. It usually strikes sufferers a few times per year in childhood and then …

How is it that thoroughly physical material beings such as ourselves can think, dream, feel,
create and understand ideas, theories and concepts? How does mere matter give rise to all …

Activity in the motor cortex predicts movements, seconds before they are initiated. This
preparatory activity has been observed across cortical layers, including in descending …

This Perspective considers the influential notion of a canonical (cortical) microcircuit in light
of recent theories about neuronal processing. Specifically, we conciliate quantitative studies …

Neural computations are currently investigated using two separate approaches: sorting
neurons into functional subpopulations or examining the low-dimensional dynamics of …

The role of the thalamus in cortical sensory transmission is well known, but its broader role
in cognition is less appreciated. Recent studies have shown thalamic engagement in …

The descending projections from motor cortex share many features with top-down or
backward connections in visual cortex; for example, corticospinal projections originate in …

A free-energy principle has been proposed recently that accounts for action, perception and
learning. This Review looks at some key brain theories in the biological (for example, neural …

Responses of sensory neurons differ across repeated measurements. This variability is
usually treated as stochasticity arising within neurons or neural circuits. However, some …