The mechanisms underlying ribonucleoprotein (RNP) granule assembly, including the basis
for establishing and maintaining RNP granules with distinct composition, are unknown. One …

The biochemical and biophysical investigation of proteins, nucleic acids, and the assemblies
that they form yields essential information to understand complex systems. Analytical …

Nucleophosmin (NPM1) is an abundant, oligomeric protein in the granular component of the
nucleolus with roles in ribosome biogenesis. Pentameric NPM1 undergoes liquid–liquid …

TDP‐43 is an RNA‐binding protein active in splicing that concentrates into membraneless
ribonucleoprotein granules and forms aggregates in amyotrophic lateral sclerosis (ALS) and …

The nucleolus is a membrane-less organelle formed through liquid-liquid phase separation
of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin …

Particles in biopharmaceutical formulations remain a hot topic in drug product development.
With new product classes emerging it is crucial to discriminate particulate active …

Repeat expansion in the C9orf72 gene is the most common cause of the neurodegenerative
disorder amyotrophic lateral sclerosis (C9-ALS) and is linked to the unconventional …

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that regulates
important functions in the central nervous system,. The ALK gene is a hotspot for …

Hydrodynamic properties are useful parameters for estimating the size and shape of
proteins and nucleic acids in solution. The calculation of such properties from structural …

Liquid–liquid phase separation underlies the membrane-less compartmentalization of cells.
Intrinsically disordered low-complexity domains (LCDs) often mediate phase separation, but …