The airway epithelium protects us from environmental insults, which we encounter with
every breath. Not only does it passively filter large particles, it also senses potential danger …

Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

Simple Summary Lung cancer is the leading cause of cancer-related death worldwide, with
an average 5-year survival rate of approximately 15%. Among the multiple histological type …

Indolent (lepidic) and aggressive (micropapillary, solid, and poorly differentiated acinar)
histologic subtypes often coexist within a tumor tissue of lung adenocarcinoma (LUAD), but …

Lung cancer is an extremely heterogeneous disease, and its treatment remains one of the
most challenging tasks in medicine. Few existing laboratory lung cancer models can …

Lung Cancer is the leading cause of cancer‐related deaths worldwide. This is mainly due to
late diagnosis and therefore advanced stage of the disease. Understanding the cell of origin …

The ability to replace defective cells in an airway with cells that can engraft, integrate, and
restore a functional epithelium could potentially cure a number of lung diseases. Progress …

Disrupted circadian rhythmicity is a prominent feature of modern society and has been
designated as a probable carcinogen by the World Health Organization. However, the …

Radiation therapy (RT) in combination with an immune checkpoint inhibitor (ICI) represents
a promising regimen for non-small cell lung cancer (NSCLC); however, the underlying …

Genes involved in the production of pulmonary surfactant are crucial for the development
and maintenance of healthy lungs. Germline mutations in surfactant-related genes cause a …