Neurodegenerative diseases are disabling and fatal neurological disorders that currently
lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a …

Skeletal muscle is a complex tissue containing tissue resident muscle stem cells (satellite
cells)(MuSCs) important for postnatal muscle growth and regeneration. Quantitative analysis …

Mutations in the acid β-glucocerebrosidase (GBA1) gene, responsible for the lysosomal
storage disorder Gaucher's disease (GD), are the strongest genetic risk factor for Parkinson's …

The establishment of cell identity during embryonic development involves the activation of
specific gene expression programmes and is underpinned by epigenetic factors including …

Flow cytometry is an invaluable tool utilized in modern biomedical research and clinical
applications requiring high throughput, high resolution particle analysis for cytometric …

Transplantation of pluripotent stem cells and their differentiated progeny has the potential to
preserve or regenerate functional pathways and improve function after central nervous …

Mutations in the SNCA gene cause autosomal dominant Parkinson's disease (PD), with loss
of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The …

In the brain, the complement system plays a crucial role in the immune response and in
synaptic elimination during normal development and disease. Here, we sought to identify …

Flow cytometry has been extensively used to define cell populations in immunology,
hematology and oncology. Here, we provide a detailed description of protocols for flow …

Human induced pluripotent stem cells (hiPSCs) are invaluable to study developmental
processes and disease mechanisms particularly in the brain. hiPSCs can be differentiated …