Acute liver failure (ALF) still represents a major therapeutic challenge for hepatologists due
to its high mortality rate as a result of multiorgan failure. Although emergency orthotopic liver …

The relative shortage of donor organs and lack of immediate availability mean that many
patients with acute liver failure die before orthotopic liver transplantation can be performed …

Background/Aims: There is an urgent need for an effective bioartificial liver system to bridge
patients with fulminant hepatic failure to liver transplantation or to regeneration of their own …

Fulminant hepatic failure (FHF), defined by the presence of hepatic encephalopathy as the
consequence of severe liver injury and originally described as occurring within 8 weeks of …

The purpose of this study was to investigate whether the efficacy of our novel extracorporeal
bioartificial liver (BAL) to support rats with complete liver ischemia (LIS) could be improved …

Extracorporeal bioartificial liver (BAL) systems based on hepatocytes need to be flushed
before clinical application, as hepatocyte culture media are not approved for medical use …

There is an urgent need for an effective liver support system to bridge patients with hepatic
failure to liver transplantation or to a stage where their own liver is able to regenerate. In the …