Chondroitin Sulfate (CS) is an anionic hetero polysaccharide possessing anti-inflammatory,
antioxidant, antitumor, anticoagulant and antithrombogenic activities. It is biodegradable and …

Cancer is an extremely complex disease involving multiple signaling pathways that enable
tumor cells to evade programmed cell death, thus making cancer treatment extremely …

Nanoparticle-based delivery systems have contributed to the recent clinical success of RNA
therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct …

Purpose Gene therapy has shown extensive potential to treat human diseases occurring
from the defection of genes like various types of cancers. The cationic polymers, as non-viral …

Nonviral delivery of plasmid (p) DNA or messenger (m) RNA is a safe and promising
therapeutic option to continuously supply therapeutic proteins into diseased tissues. In most …

In recent years, the naturally occurring polysaccharides captured an increasing amount of
attention in the field of drug/gene delivery systems owing to their outstanding propensities …

Gene therapy is a promising approach for treating diseases that are closely associated with
excessive apoptosis, because the gene can effectively and sustainably introduce anti …

Polyplexes are required to be equipped with multiple functionalities to accomplish adequate
structure stability and gene transfection efficacy for gene therapy. Herein, a 4-carboxy-3 …

Cancer vaccines have been widely explored as a key tool for effective cancer
immunotherapy. Despite a convincing rationale behind cancer vaccines, extensive past …

Effective targeting drug delivery for cancer therapy still remains a formidable challenge due
to the complication and heterogeneity of malignant tumors. Herein, a multifunctional …