Peroxisome proliferator-activated receptor gamma (PPARγ) has been implicated in the
pathology of numerous diseases involving diabetes, stroke, cancer, or obesity. It is …

The past 20 years have resulted in unprecedented progress in understanding brain energy
metabolism and its role in health and disease. In this review, which was initiated at the 14th …

MicroRNA-21 (miR-21) contributes to the pathogenesis of fibrogenic diseases in multiple
organs, including the kidneys, potentially by silencing metabolic pathways that are critical for …

Astrocyte-mediated inflammation is associated with degenerative pathologies such as
Alzheimer's and Parkinson's diseases and multiple sclerosis. The acute inflammation and …

According to World Health Organization estimates, type 2 diabetes (T2D) is an epidemic
(particularly in under development countries) and a socio-economic challenge. This is even …

Cerebral ischemic injury is a leading cause of death and long-term disability throughout the
world. Peroxisome proliferator-activated receptor gamma (PPAR-ɣ) is a ligand-activated …

Signalling lipids are known to control a wide array of cellular processes, including cell
proliferation, apoptosis, migration, and energy metabolism. Fatty acids and their derivatives …

Cerebral ischemia-reperfusion injury (CI/RI) is a complex pathological process that often
occurs secondary to trauma, surgery, and shock. Peroxisome proliferator activated receptor …

Rationale: Demyelination is a major component of white matter injury, characterized by
oligodendrocyte (OL) death and myelin sheath loss, which result in memory loss and …

To an exceptional degree, and through multiple mechanisms, the PPARg system rapidly
senses cellular stress, and functions in the CNS in glial cells, neurons, and cerebrovascular …