Molecular insight into the therapeutic effects of stem cell-derived exosomes in respiratory diseases and the potential for pulmonary delivery

MH Azhdari, N Goodarzi, M Doroudian… - International Journal of …, 2022 - mdpi.com
Respiratory diseases are the cause of millions of deaths annually around the world. Despite
the recent growth of our understanding of underlying mechanisms contributing to the …

Not all nebulizers are created equal: Considerations in choosing a nebulizer for aerosol delivery during mechanical ventilation

R MacLoughlin, I Martin-Loeches - Expert Review of Respiratory …, 2023 - Taylor & Francis
Introduction Aerosol therapy is commonly prescribed in the mechanically ventilated patient.
Jet nebulizers (JN) and vibrating mesh nebulizers (VMN) are the most common nebulizer …

Aerosol therapy in adult critically ill patients: a consensus statement regarding aerosol administration strategies during various modes of respiratory support

J Li, K Liu, S Lyu, G Jing, B Dai, R Dhand, HL Lin… - Annals of intensive …, 2023 - Springer
Background Clinical practice of aerosol delivery in conjunction with respiratory support
devices for critically ill adult patients remains a topic of controversy due to the complexity of …

Aerosol delivery in models of pediatric high flow nasal oxygen and mechanical ventilation

R Wang, CO Leime, W Gao… - Pediatric …, 2023 - Wiley Online Library
Background Aerosol drug delivery during high flow nasal oxygen (HFNO) and invasive
mechanical ventilation (IMV) are key respiratory care strategies available for the treatment of …

Nebuliser therapy in critical care: The past, present and future

A Arnott, M Watson, M Sim - Journal of The Intensive Care …, 2024 - journals.sagepub.com
Nebulisers are devices that reduce a body of liquid into a fine aerosol suitable for inhalation.
Utilising the efficiency of pulmonary drug absorption, they offer a safe and powerful modality …

Inhaled exosomes genetically manipulated to overexpress CD24 (EXO-CD24) as a compassionate use in severe ARDS patients

O Green, G Shenberg, R Baruch, L Argaman, T Levin… - Biomedicines, 2023 - mdpi.com
Rationale: Acute respiratory distress syndrome (ARDS) is a major global health concern with
a significant unmet need. EXO-CD24 is delivered via inhalation-reduced cytokines and …

An in vitro study of the effects of respiratory circuit setup and parameters on aerosol delivery during mechanical ventilation

L Reilly, M Mac Giolla Eain, S Murphy… - Frontiers in …, 2024 - frontiersin.org
Introduction Aerosol therapy is often prescribed concurrently during invasive mechanical
ventilation (IMV). This study determines the effects of nebuliser position, circuit …

Pulmonary drug delivery devices and nanosystems as potential treatment strategies for acute respiratory distress syndrome (ARDS)

CT Dhege, P Kumar, YE Choonara - International Journal of Pharmaceutics, 2024 - Elsevier
Despite advances in drug delivery technologies, treating acute respiratory distress
syndrome (ARDS) is challenging due to pathophysiological barriers such as lung injury …

The impact of head model choice on the in vitro evaluation of aerosol drug delivery

L Gallagher, M Joyce, B Murphy, M Mac Giolla Eain… - Pharmaceutics, 2021 - mdpi.com
There are variations in the values reported for aerosol drug delivery across in vitro
experiments throughout the published literature, and often with the same devices or similar …

[HTML][HTML] In vitro evaluation of the potential use of snake-derived peptides in the treatment of respiratory infections using inhalation therapy: A proof of concept study

S Creane, M Joyce, R MacLoughlin, S Weldon… - European Journal of …, 2023 - Elsevier
Inhalation therapy using nebulisers is an attractive non-invasive route for drug delivery,
particularly for the treatment of lung infections with anti-inflammatory and anti-microbial …