Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Photosynthetic semiconductor biohybrids for solar-driven biocatalysis

S Cestellos-Blanco, H Zhang, JM Kim, Y Shen… - Nature Catalysis, 2020 - nature.com
Photosynthetic semiconductor biohybrids integrate the best attributes of biological whole-
cell catalysts and semiconducting nanomaterials. Enzymatic machinery enveloped in its …

Conversion of Escherichia coli to generate all biomass carbon from CO2

S Gleizer, R Ben-Nissan, YM Bar-On, N Antonovsky… - Cell, 2019 - cell.com
The living world is largely divided into autotrophs that convert CO 2 into biomass and
heterotrophs that consume organic compounds. In spite of widespread interest in renewable …

Metabolic engineering strategies to enable microbial utilization of C1 feedstocks

W Jiang, D Hernández Villamor, H Peng… - Nature Chemical …, 2021 - nature.com
Abstract One-carbon (C1) substrates are preferred feedstocks for the biomanufacturing
industry and have recently gained attention owing to their natural abundance, low …

Revisiting solar energy flow in nanomaterial-microorganism hybrid systems

J Liang, K Xiao, X Wang, T Hou, C Zeng, X Gao… - Chemical …, 2024 - ACS Publications
Nanomaterial-microorganism hybrid systems (NMHSs), integrating semiconductor
nanomaterials with microorganisms, present a promising platform for broadband solar …

The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO2

T Gassler, M Sauer, B Gasser, M Egermeier… - Nature …, 2020 - nature.com
The methylotrophic yeast Pichia pastoris is widely used in the manufacture of industrial
enzymes and pharmaceuticals. Like most biotechnological production hosts, P. pastoris is …

Synthetic biology strategies for microbial biosynthesis of plant natural products

A Cravens, J Payne, CD Smolke - Nature communications, 2019 - nature.com
Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …

[HTML][HTML] Pseudomonas putida as a functional chassis for industrial biocatalysis: from native biochemistry to trans-metabolism

PI Nikel, V de Lorenzo - Metabolic engineering, 2018 - Elsevier
The itinerary followed by Pseudomonas putida from being a soil-dweller and plant colonizer
bacterium to become a flexible and engineer-able platform for metabolic engineering stems …

Generation of an Escherichia coli strain growing on methanol via the ribulose monophosphate cycle

P Keller, MA Reiter, P Kiefer, T Gassler… - Nature …, 2022 - nature.com
Methanol is a liquid with high energy storage capacity that holds promise as an alternative
substrate to replace sugars in the biotechnology industry. It can be produced from CO2 or …

Escherichia coli as a host for metabolic engineering

S Pontrelli, TY Chiu, EI Lan, FYH Chen, P Chang… - Metabolic …, 2018 - Elsevier
Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …