Role of oxidative stress in ocular diseases: a balancing act

DY Shu, S Chaudhary, KS Cho, A Lennikov, WP Miller… - Metabolites, 2023 - mdpi.com
Redox homeostasis is a delicate balancing act of maintaining appropriate levels of
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …

Lutein supplementation for eye diseases

LH Li, JCY Lee, HH Leung, WC Lam, Z Fu, ACY Lo - Nutrients, 2020 - mdpi.com
Lutein is one of the few xanthophyll carotenoids that is found in high concentration in the
macula of human retina. As de novo synthesis of lutein within the human body is impossible …

The human lens: an antioxidant-dependent tissue revealed by the role of caffeine

M Ruiss, O Findl, M Kronschläger - Ageing research reviews, 2022 - Elsevier
Cataract is the leading cause of blindness worldwide and surgery is the only option to treat
the disease. Although the surgery is considered to be relatively safe, complications may …

Etiology of posterior subcapsular cataracts based on a review of risk factors including aging, diabetes, and ionizing radiation

RB Richardson, EA Ainsbury, CR Prescott… - International journal of …, 2020 - Taylor & Francis
Purpose Since the exact development of posterior subcapsular cataracts (PSCs) is poorly
understood, we review various risk factors and propose a two-stage etiology for PSCs …

Hallmarks of lens aging and cataractogenesis

TFL Wishart, M Flokis, DY Shu, SJ Das… - Experimental Eye …, 2021 - Elsevier
Lens homeostasis and transparency are dependent on the function and intercellular
communication of its epithelia. While the lens epithelium is uniquely equipped with …

Regulation of lens water content: Effects on the physiological optics of the lens

PJ Donaldson, Y Chen, RS Petrova, AC Grey… - Progress in Retinal and …, 2023 - Elsevier
The lens is an important determinant of overall vision quality whose refractive and
transparent properties change throughout life. Alterations to the refractive properties of the …

Advances in drug therapy and delivery for cataract treatment

BJ Lee, NA Afshari - Current Opinion in Ophthalmology, 2023 - journals.lww.com
Advances in drug therapy and delivery for cataract treatment : Current Opinion in Ophthalmology
Advances in drug therapy and delivery for cataract treatment : Current Opinion in …

Glutathione and glutathione disulfide–their biomedical and pharmaceutical applications

X Guan - Medicinal Chemistry Research, 2023 - Springer
Glutathione (GSH) is an endogenous tripeptide (Glu-Cys-Gly) and the most abundant
endogenous antioxidant. It protects the body against oxidative stress and reactive …

Biliverdin/Bilirubin Redox Pair Protects Lens Epithelial Cells against Oxidative Stress in Age‐Related Cataract by Regulating NF‐κB/iNOS and Nrf2/HO‐1 Pathways

Y Huang, J Li, W Li, N Ai, H Jin - Oxidative medicine and …, 2022 - Wiley Online Library
Age‐related cataract (ARC) is the leading cause of vision impairment globally. It has been
widely accepted that excessive reactive oxygen species (ROS) accumulation in lens …

Physiological mechanisms regulating lens transport

AA Giannone, L Li, C Sellitto, TW White - Frontiers in Physiology, 2021 - frontiersin.org
The transparency and refractive properties of the lens are maintained by the cellular
physiology provided by an internal microcirculation system that utilizes spatial differences in …