The role of oxidative stress in ovarian aging: a review

F Yan, Q Zhao, Y Li, Z Zheng, X Kong, C Shu… - Journal of ovarian …, 2022 - Springer
Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

Metabolic syndrome and PCOS: Pathogenesis and the role of metabolites

W Chen, Y Pang - Metabolites, 2021 - mdpi.com
Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases among
women of reproductive age and is associated with many metabolic manifestations, such as …

Activating cGAS–STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis

R Ding, H Li, Y Liu, W Ou, X Zhang, H Chai… - Journal of …, 2022 - Springer
Background Neuroinflammation-induced injury is intimately associated with poor prognosis
in patients with cerebral venous sinus thrombosis (CVST). The cyclic GMP-AMP synthase …

The role of inflammasomes in human diseases and their potential as therapeutic targets

J Yao, K Sterling, Z Wang, Y Zhang… - Signal Transduction and …, 2024 - nature.com
Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

The Release of Peripheral Immune Inflammatory Cytokines Promote an Inflammatory Cascade in PCOS Patients via Altering the Follicular Microenvironment

Y Liu, H Liu, Z Li, H Fan, X Yan, X Liu, J Xuan… - Frontiers in …, 2021 - frontiersin.org
Background Hormones and immune imbalance are critical factors in polycystic ovary
syndrome (PCOS). The alternation of immune microenvironment of oocytes may play a …

Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells

Y Chen, Y Zhao, C Miao, L Yang, R Wang… - Journal of Ovarian …, 2022 - Springer
Background Exposure to cyclophosphamide (CTX) induces premature ovarian insufficiency
(POI). Quercetin is a natural flavonoid that exhibits anti-inflammatory and antioxidant …

Oxidative stress and antioxidant imbalance in ovulation disorder in patients with polycystic ovary syndrome

W Li, C Liu, Q Yang, Y Zhou, M Liu, H Shan - Frontiers in Nutrition, 2022 - frontiersin.org
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease that is
characterized by oligo-ovulation or anovulation, hyperandrogenism, and polycystic ovaries …

The Role of NLRP3 Inflammasome in Obesity and PCOS—A Systematic Review and Meta-Analysis

SA Alenezi, R Khan, L Snell, S Aboeldalyl… - International Journal of …, 2023 - mdpi.com
Inflammasomes have recently been implicated in the pathogenesis of several chronic
inflammatory disorders, such as diabetes and obesity. The aim of this meta-analysis was to …

Ursolic acid reverses liver fibrosis by inhibiting NOX4/NLRP3 inflammasome pathways and bacterial dysbiosis

Y Nie, Q Liu, W Zhang, Y Wan, C Huang, X Zhu - Gut Microbes, 2021 - Taylor & Francis
Activation of the NOX4/NLRP3 inflammasome pathway has been associated with fibrosis in
other organs. An imbalance in intestinal bacteria is an important driving factor of liver fibrosis …

Hydrogen sulfide exposure induces pyroptosis in the trachea of broilers via the regulatory effect of circRNA-17828/miR-6631-5p/DUSP6 crosstalk on ROS production

N Song, X Li, Y Cui, T Zhang, S Xu, S Li - Journal of hazardous materials, 2021 - Elsevier
Hydrogen sulfide (H 2 S) is an air pollutant to cause tracheal injury. Pyroptosis is
responsible for tissue injury through reactive oxygen species (ROS) production. Competitive …